| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Tik, Ronald Sladky, Caroline Di Bernardi Luft, David Willinger, André Hoffmann, Michael J Banissy, Joydeep Bhattacharya, Christian Windischberge. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human brain mapping. vol 39. issue 8. 2019-05-21. PMID:29665228. |
besides the finding on cortical involvement of the left anterior middle temporal gyrus (amtg), here we showed for the first time robust subcortical activity changes related to insightful problem solving in the bilateral thalamus, hippocampus, and the dopaminergic midbrain comprising ventral tegmental area (vta), nucleus accumbens (nacc), and caudate nucleus. |
2019-05-21 |
2023-08-13 |
human |
| Florian Groessl, Thomas Munsch, Susanne Meis, Johannes Griessner, Joanna Kaczanowska, Pinelopi Pliota, Dominic Kargl, Sylvia Badurek, Klaus Kraitsy, Arash Rassoulpour, Johannes Zuber, Volkmar Lessmann, Wulf Haubensa. Dorsal tegmental dopamine neurons gate associative learning of fear. Nature neuroscience. vol 21. issue 7. 2019-05-16. PMID:29950668. |
these findings add a new module to the midbrain dopaminergic circuit architecture underlying associative reinforcement learning and identify vpdrd neurons as a critical component of pavlovian fear conditioning. |
2019-05-16 |
2023-08-13 |
Not clear |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Social reward monitoring and valuation in the macaque brain. Nature neuroscience. vol 21. issue 10. 2019-05-16. PMID:30224807. |
medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. |
2019-05-16 |
2023-08-13 |
monkey |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Social reward monitoring and valuation in the macaque brain. Nature neuroscience. vol 21. issue 10. 2019-05-16. PMID:30224807. |
recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. |
2019-05-16 |
2023-08-13 |
monkey |
| Luke T Coddington, Joshua T Dudma. The timing of action determines reward prediction signals in identified midbrain dopamine neurons. Nature neuroscience. vol 21. issue 11. 2019-05-16. PMID:30323275. |
the activity of midbrain dopaminergic neurons is thought to convey a critical teaching signal: reward-prediction error. |
2019-05-16 |
2023-08-13 |
mouse |
| Luke T Coddington, Joshua T Dudma. The timing of action determines reward prediction signals in identified midbrain dopamine neurons. Nature neuroscience. vol 21. issue 11. 2019-05-16. PMID:30323275. |
although reward-prediction error signals are thought to be essential to learning, little is known about the dynamic changes in the activity of midbrain dopaminergic neurons as animals learn about novel sensory cues and appetitive rewards. |
2019-05-16 |
2023-08-13 |
mouse |
| Sarah A McClymont, Paul W Hook, Alexandra I Soto, Xylena Reed, William D Law, Samuel J Kerans, Eric L Waite, Nicole J Briceno, Joey F Thole, Michael G Heckman, Nancy N Diehl, Zbigniew K Wszolek, Cedric D Moore, Heng Zhu, Jennifer A Akiyama, Diane E Dickel, Axel Visel, Len A Pennacchio, Owen A Ross, Michael A Beer, Andrew S McCallio. Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. American journal of human genetics. vol 103. issue 6. 2019-05-14. PMID:30503521. |
the progressive loss of midbrain (mb) dopaminergic (da) neurons defines the motor features of parkinson disease (pd), and modulation of risk by common variants in pd has been well established through genome-wide association studies (gwass). |
2019-05-14 |
2023-08-13 |
mouse |
| Guo-Qing Wang, Bei Zhang, Xue-Mei He, Dai-Di Li, Jing-Shan Shi, Feng Zhan. Naringenin targets on astroglial Nrf2 to support dopaminergic neurons. Pharmacological research. vol 139. 2019-05-14. PMID:30527894. |
in primary rat midbrain neuron-glia co-cultures, nar conferred neurotrophic effects to support dopaminergic (da) neurons survival in the concentration- and time-dependent manners. |
2019-05-14 |
2023-08-13 |
rat |
| Hideya Sakaguchi, Jun Takahash. Cell-based therapies for Parkinson's disease. Nihon rinsho. Japanese journal of clinical medicine. vol 75. issue 1. 2019-05-08. PMID:30566308. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders that is characterized by the loss of a9 midbrain dopaminergic neurons. |
2019-05-08 |
2023-08-13 |
Not clear |
| Ali Fathi, Mehdi Mirzaei, Banafsheh Dolatyar, Mehdi Sharifitabar, Mahnaz Bayat, Ebrahim Shahbazi, Jaesuk Lee, Mohammad Javan, Su-Chun Zhang, Vivek Gupta, Bonghee Lee, Paul A Haynes, Hossein Baharvand, Ghasem Hosseini Salekde. Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models. Molecular & cellular proteomics : MCP. vol 17. issue 9. 2019-05-06. PMID:29848781. |
here we report the generation of a lim homeobox transcription factor 1 alpha (lmx1a) knock-in gfp reporter human embryonic stem cell (hesc) line that marks the early dopaminergic progenitors during neural differentiation to find reliable membrane protein markers for isolation of midbrain dopaminergic neurons. |
2019-05-06 |
2023-08-13 |
human |
| Hao Liu, Lin Zhong, Chunling Zhao, Xiaolei Tang, Jun Yang, Lei Gon. Quantitative analysis on secretion level of CDNF regulated by two key α-helices in CDNF protein. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30548741. |
cerebral dopamine neurotrophic factor (cdnf) has been considered as potent candidates for the therapy of parkinson's disease (pd) for which can promote the survival of midbrain dopaminergic neurons. |
2019-04-30 |
2023-08-13 |
Not clear |
| Maria Nguyen, Yvette C Wong, Daniel Ysselstein, Alex Severino, Dimitri Krain. Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease. Trends in neurosciences. vol 42. issue 2. 2019-04-19. PMID:30509690. |
here we discuss the recent work on the contribution of dysfunctional sve to midbrain dopaminergic neurons' selective vulnerability and highlight pathways that demonstrate the interplay of synaptic, mitochondrial, and lysosomal dysfunction in the pathogenesis of pd. |
2019-04-19 |
2023-08-13 |
Not clear |
| Charlotte M Ermine, Jordan L Wright, Stefano Frausin, Jessica A Kauhausen, Clare L Parish, Davor Stanic, Lachlan H Thompso. Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis. Hippocampus. vol 28. issue 5. 2019-04-16. PMID:29431270. |
key pathological features of parkinson's disease (pd) include the progressive degeneration of midbrain dopaminergic (da) neurons and hindbrain noradrenergic (na) neurons. |
2019-04-16 |
2023-08-13 |
rat |
| Linfang Chen, Liujun Xue, Jinlong Zheng, Xiangyang Tian, Yingdong Zhang, Qiang Ton. PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:29885849. |
our results show that gw501516 reduced movement impairment in pd mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and nlrp3 inflammasome activation in the midbrain of pd mice. |
2019-04-16 |
2023-08-13 |
mouse |
| François-Xavier Blaudin de Thé, Hocine Rekaik, Eugenie Peze-Heidsieck, Olivia Massiani-Beaudoin, Rajiv L Joshi, Julia Fuchs, Alain Prochiant. Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. The EMBO journal. vol 37. issue 15. 2019-04-16. PMID:29941661. |
we report that line-1 are expressed in substantia nigra ventral midbrain dopaminergic neurons, a class of neurons that degenerate in parkinson's disease. |
2019-04-16 |
2023-08-13 |
Not clear |
| Diana Lupu, Mukesh K Varshney, Daniel Mucs, José Inzunza, Ulf Norinder, Felicia Loghin, Ivan Nalvarte, Joëlle Rüeg. Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro. Molecular pharmacology. vol 94. issue 4. 2019-04-16. PMID:30115672. |
fluoxetine affects differentiation of midbrain dopaminergic neurons in vitro. |
2019-04-16 |
2023-08-13 |
mouse |
| Diana Lupu, Mukesh K Varshney, Daniel Mucs, José Inzunza, Ulf Norinder, Felicia Loghin, Ivan Nalvarte, Joëlle Rüeg. Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro. Molecular pharmacology. vol 94. issue 4. 2019-04-16. PMID:30115672. |
mouse neuronal precursors were differentiated into midbrain dopaminergic precursor cells (mdpcs) and concomitantly exposed to clinically relevant doses of flx. |
2019-04-16 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. |
2019-04-11 |
2023-08-13 |
mouse |
| W F Alsanie, V Penna, M Schachner, L H Thompson, C L Paris. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28839197. |
homophilic binding of the neural cell adhesion molecule chl1 regulates development of ventral midbrain dopaminergic pathways. |
2019-04-11 |
2023-08-13 |
Not clear |
| W F Alsanie, V Penna, M Schachner, L H Thompson, C L Paris. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28839197. |
abnormal development of ventral midbrain (vm) dopaminergic (da) pathways, essential for motor and cognitive function, may underpin a number of neurological disorders and thereby highlight the importance of understanding the birth and connectivity of the associated neurons. |
2019-04-11 |
2023-08-13 |
Not clear |