| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
while the specification and differentiation of these neurons have been extensively studied, the molecular mechanisms that regulate midbrain dopaminergic axon growth and target innervation are less clear. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
here we show that the transcription factor zeb2 cell-autonomously represses smad signalling to limit midbrain dopaminergic axon growth and target innervation. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
zeb2 levels are downregulated in the embryonic rodent midbrain during the period of dopaminergic axon growth, when bmp pathway components are upregulated. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
consequently there is dopaminergic hyperinnervation of the striatum, without an increase in the numbers of midbrain dopaminergic neurons, in conditional zeb2 (nestin-cre based) knockout mice. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
therefore, these findings reveal a new mechanism for the regulation of midbrain dopaminergic axon growth during central nervous system development. |
2019-03-25 |
2023-08-13 |
mouse |
| José Luis Pérez-López, Rubén Contreras-López, Josué O Ramírez-Jarquín, Fatuel Tecuapetl. Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons. Frontiers in neural circuits. vol 12. 2019-03-25. PMID:30210308. |
direct glutamatergic signaling from midbrain dopaminergic neurons onto pyramidal prefrontal cortex neurons. |
2019-03-25 |
2023-08-13 |
Not clear |
| Xiaolai Zhou, Björn Spitta. Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro. Neurotoxicity research. vol 33. issue 4. 2019-03-20. PMID:29188488. |
lipopolysaccharide-induced microglia activation promotes the survival of midbrain dopaminergic neurons in vitro. |
2019-03-20 |
2023-08-13 |
Not clear |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
preclinical studies have revealed that specific mglur subtypes mediate significant neuroprotective effects that reduce toxin-induced midbrain dopaminergic neuronal death in animal models of pd. |
2019-03-14 |
2023-08-13 |
human |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
it is noteworthy that these protective effects extend beyond midbrain dopaminergic neurons to include other monoaminergic cell groups for some mglurs. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
however, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. |
2019-03-14 |
2023-08-13 |
human |
| Kyle Denton, Yongchao Mou, Chong-Chong Xu, Dhruvi Shah, Jaerak Chang, Craig Blackstone, Xue-Jun L. Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias. Human molecular genetics. vol 27. issue 14. 2019-03-12. PMID:29726929. |
in patient ipsc-derived telencephalic glutamatergic and midbrain dopaminergic neurons, neurite number, length and branching are significantly reduced, recapitulating disease-specific phenotypes. |
2019-03-12 |
2023-08-13 |
Not clear |
| Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Pen. Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 118. issue 1 Pt 3. 2019-03-12. PMID:30031602. |
valproate is protective against 6-ohda-induced dopaminergic neurodegeneration in rodent midbrain: a potential role of bdnf up-regulation. |
2019-03-12 |
2023-08-13 |
Not clear |
| Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi Kawas. Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson's Disease Model Rats. Neuroscience. vol 386. 2019-03-11. PMID:29932984. |
although recent progress in the use of human ips cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases. |
2019-03-11 |
2023-08-13 |
human |
| Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F Gorio, Massimiliano Mazza, Anna Maria Di Giuli. Counteracting neuroinflammation in experimental Parkinson's disease favors recovery of function: effects of Er-NPCs administration. Journal of neuroinflammation. vol 15. issue 1. 2019-03-11. PMID:30501635. |
parkinson's disease (pd) is the second most common neurodegenerative disease, presenting with midbrain dopaminergic neurons degeneration. |
2019-03-11 |
2023-08-13 |
Not clear |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
local field potentials reflect dopaminergic and non-dopaminergic activities within the primate midbrain. |
2019-03-11 |
2023-08-13 |
monkey |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
together, lfps provide novel insights into the multidimensional processing of reward information subserved by dopaminergic and other components of the midbrain. |
2019-03-11 |
2023-08-13 |
monkey |
| Bianca Marchett. Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 19. issue 12. 2019-03-08. PMID:30477246. |
this review highlights a wnt/β-catenin/glial connection in parkinson's disease (pd), the most common movement disorder characterized by the selective death of midbrain dopaminergic (mdaergic) neuronal cell bodies in the subtantia nigra pars compacta (snpc) and gliosis. |
2019-03-08 |
2023-08-13 |
mouse |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
furthermore, nav1.3 was not only expressed in th-positive dopaminergic neurons of the ipsilateral and contralateral sn, but also in nestin-positive neural progenitor cells surrounding the ipsilateral sn and the midline region adjacent to the ipsilateral sn in the midbrain at 49 days postlesion. |
2019-03-07 |
2023-08-13 |
rat |