| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ima Trempler, Ellen Binder, Nadiya El-Sourani, Patrick Schiffler, Jan-Gerd Tenberge, Anne-Marike Schiffer, Gereon R Fink, Ricarda I Schubot. Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson's disease. Brain structure & function. vol 223. issue 5. 2019-02-27. PMID:29374792. |
parkinson's disease (pd), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. |
2019-02-27 |
2023-08-13 |
human |
| Indrani Datta, Kavina Ganapathy, Rema Razdan, Ramesh Bhond. Location and Number of Astrocytes Determine Dopaminergic Neuron Survival and Function Under 6-OHDA Stress Mediated Through Differential BDNF Release. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:28965325. |
however, striking differences were observed in dopaminergic neuronal (th) cell survival in the presence of midbrain astrocytes in comparison to forebrain and hindbrain astrocytes at all seeding numbers. |
2019-02-26 |
2023-08-13 |
Not clear |
| Yan-Hua Ren, Xue-Yuan Niu, Hou-Ju Huang, Xiao-Di Hao, Peng-Xiang Wang, Yi-Li Chi, Yu-Qiang Ding, Min Lia. Dopamine neuron loss by selective deletion of autophagy-related gene 5 is not exacerbated by MPTP toxicity in midbrain. Neuroscience letters. vol 675. 2019-02-22. PMID:29175031. |
parkinson's disease (pd) is a progressive neurological disease, one of the pathological characteristics is a gradual loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta (snpc). |
2019-02-22 |
2023-08-13 |
mouse |
| Qiu T Ruan, Neema Yazdani, Jacob A Beierle, Kathryn M Hixson, Kristen E Hokenson, Daniel J Apicco, Kimberly P Luttik, Karen Zheng, Brandon F Maziuk, Peter E A Ash, Karen K Szumlinski, Shelley J Russek, Benjamin Wolozin, Camron D Bryan. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neuroscience letters. vol 684. 2019-02-20. PMID:30003938. |
methamphetamine initiates post-synaptic d1 dopamine receptor signaling indirectly by binding to pre-synaptic dopamine transporters and vesicular monoamine transporters of midbrain dopaminergic neurons which triggers reverse transport and accumulation of dopamine at the synapse. |
2019-02-20 |
2023-08-13 |
rat |
| Yujung Chang, Junsang Yoo, Hongwon Kim, Hi-Joon Park, Songhee Jeon, Jongpil Ki. Salusin-β mediate neuroprotective effects for Parkinson's disease. Biochemical and biophysical research communications. vol 503. issue 3. 2019-02-18. PMID:30017195. |
importantly, intranasal administration of salusin-β in a pd mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. |
2019-02-18 |
2023-08-13 |
mouse |
| Anna O Ermakova, Franziska Knolle, Azucena Justicia, Edward T Bullmore, Peter B Jones, Trevor W Robbins, Paul C Fletcher, Graham K Murra. Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29748629. |
anova revealed significant (p < 0.05 family-wise error corrected) prediction-error signalling differences between groups in the dopaminergic midbrain and right middle frontal gyrus (dorsolateral prefrontal cortex, dlpfc). |
2019-02-14 |
2023-08-13 |
human |
| Ji Young Kim, Jae Souk Lee, Hyun Sub Hwang, Dongjin R Lee, Chul-Yong Park, Sung Jun Jung, Young Rang You, Dae-Sung Kim, Dong-Wook Ki. Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells. Experimental & molecular medicine. vol 50. issue 4. 2019-02-11. PMID:29650976. |
activating wnt signal has been a strategy for differentiating human pluripotent stem cells (pscs) into midbrain dopaminergic (da) neurons; however, the underlying molecular mechanism(s) of how the wnt signal drives posterior fate remained unclear. |
2019-02-11 |
2023-08-13 |
human |
| Birte Becker, Melek Demirbas, Sonja Johann, Adib Zendedel, Cordian Beyer, Hans Clusmann, Stefan Jean-Pierre Haas, Andreas Wree, Sonny Kian Hwie Tan, Markus Kip. Effect of Intrastriatal 6-OHDA Lesions on Extrastriatal Brain Structures in the Mouse. Molecular neurobiology. vol 55. issue 5. 2019-02-08. PMID:28616718. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor and non-motor symptoms. |
2019-02-08 |
2023-08-13 |
mouse |
| Gourav R Choudhury, Marcel M Daad. Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson's disease. PloS one. vol 13. issue 8. 2019-02-08. PMID:30138454. |
however, this model is established through the specific loss of midbrain dopaminergic neurons, while our current knowledge reflects the reality of parkinson's disease as a multisystem disease. |
2019-02-08 |
2023-08-13 |
marmoset |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
dopaminergic neurotoxicity of taclo was determined in midbrain organotypic cultures from rat pups. |
2019-02-04 |
2023-08-13 |
mouse |
| Hanna Kim, Carles Calatayud, Sanjib Guha, Irene Fernández-Carasa, Laura Berkowitz, Iria Carballo-Carbajal, Mario Ezquerra, Rubén Fernández-Santiago, Pankaj Kapahi, Ángel Raya, Antonio Miranda-Vizuete, Jose Miguel Lizcano, Miquel Vila, Kim A Caldwell, Guy A Caldwell, Antonella Consiglio, Esther Dalf. The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29429047. |
parkinson's disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the substantia nigra of brain patients. |
2019-02-04 |
2023-08-13 |
human |
| Robert Lindroos, Matthijs C Dorst, Kai Du, Marko Filipović, Daniel Keller, Maya Ketzef, Alexander K Kozlov, Arvind Kumar, Mikael Lindahl, Anu G Nair, Juan Pérez-Fernández, Sten Grillner, Gilad Silberberg, Jeanette Hellgren Kotalesk. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Frontiers in neural circuits. vol 12. 2019-02-01. PMID:29467627. |
dopaminergic afferents from the midbrain and local cholinergic interneurons play crucial roles for basal ganglia function, and striatal signaling via the striosomes in turn regulates the midbrain dopaminergic system directly and via the lateral habenula. |
2019-02-01 |
2023-08-13 |
Not clear |
| Tomohiko Yoshizawa, Makoto Ito, Kenji Doy. Reward-Predictive Neural Activities in Striatal Striosome Compartments. eNeuro. vol 5. issue 1. 2019-01-29. PMID:29430520. |
accordingly, it has been difficult to identify striosomal neurons in electrophysiological recordings and it has been unclear whether striosomal neurons, which project to midbrain dopaminergic neurons, engage in reward prediction. |
2019-01-29 |
2023-08-13 |
mouse |
| Jinhua Chen, Ying Chen, Jiali P. Leucine-Rich Repeat Kinase 2 in Parkinson's Disease: Updated from Pathogenesis to Potential Therapeutic Target. European neurology. vol 79. issue 5-6. 2019-01-23. PMID:29705795. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the midbrain. |
2019-01-23 |
2023-08-13 |
Not clear |
| Marcello D'Amelio, Stefano Puglisi-Allegra, Nicola Mercur. The role of dopaminergic midbrain in Alzheimer's disease: Translating basic science into clinical practice. Pharmacological research. vol 130. 2019-01-18. PMID:29391234. |
the role of dopaminergic midbrain in alzheimer's disease: translating basic science into clinical practice. |
2019-01-18 |
2023-08-13 |
Not clear |
| Marcello D'Amelio, Stefano Puglisi-Allegra, Nicola Mercur. The role of dopaminergic midbrain in Alzheimer's disease: Translating basic science into clinical practice. Pharmacological research. vol 130. 2019-01-18. PMID:29391234. |
among the subcortical structures, the dopaminergic midbrain plays a pivotal role in tuning cortical functions that commonly result altered in many neurological and psychiatric disorders. |
2019-01-18 |
2023-08-13 |
Not clear |
| Marcello D'Amelio, Stefano Puglisi-Allegra, Nicola Mercur. The role of dopaminergic midbrain in Alzheimer's disease: Translating basic science into clinical practice. Pharmacological research. vol 130. 2019-01-18. PMID:29391234. |
incidentally, extensive neuropathological observations support a strong link between structural alterations of the dopaminergic midbrain and significant behavioural symptomatology observed in patients suffering from alzheimer 's disease(ad). |
2019-01-18 |
2023-08-13 |
Not clear |
| Elisabeth Zieger, Thurston C Lacalli, Mario Pestarino, Michael Schubert, Simona Candian. The origin of dopaminergic systems in chordate brains: insights from amphioxus. The International journal of developmental biology. vol 61. issue 10-11-12. 2019-01-10. PMID:29319121. |
this population lies in a cns domain now thought to comprise a combined vertebrate diencephalon plus mesencephalon, the implication being that dopaminergic nuclei in both of these brain regions could derive from a single dien-mesencephalic population in the last common ancestor of amphioxus and vertebrates. |
2019-01-10 |
2023-08-13 |
Not clear |
| Emanuel Berger, Chiara Magliaro, Nicole Paczia, Anna S Monzel, Paul Antony, Carole L Linster, Silvia Bolognin, Arti Ahluwalia, Jens C Schwambor. Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a chip. vol 18. issue 20. 2019-01-07. PMID:30204191. |
in hmos, neuroepithelial stem cells (nescs) give rise to functional midbrain dopaminergic (mda) neurons that are selectively degenerating during pd. |
2019-01-07 |
2023-08-13 |
human |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
role of dopamine d2/d3 receptors in development, plasticity, and neuroprotection in human ipsc-derived midbrain dopaminergic neurons. |
2019-01-01 |
2023-08-13 |
human |