| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
the role of dopamine d2 and d3 receptors (d2r/d3r), located on midbrain dopaminergic (da) neurons, in the regulation of da synthesis and release and in da neuron homeostasis has been extensively investigated in rodent animal models. |
2019-01-01 |
2023-08-13 |
human |
| Dan Luo, Jia Zhao, Yuanyuan Cheng, Simon Ming-Yuen Lee, Jianhui Ron. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP Molecular neurobiology. vol 55. issue 3. 2018-12-31. PMID:28321769. |
consistently, paca also increased ngf levels in dopaminergic pc12 cells and primary rat midbrain neurons against n-methyl-4-phenylpyridinium iodide (mpp |
2018-12-31 |
2023-08-13 |
mouse |
| Saba Khanam, Falaq Naz, Fahad Ali, Rahul Smita Jyoti, Ambreen Fatima, Wasi Khan, Braj Raj Singh, A H Naqvi, Yasir Hasan Siddiqu. Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease. Toxicology mechanisms and methods. vol 28. issue 9. 2018-12-26. PMID:30019977. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2018-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Xiaotian Sun, Pascaline Aimé, David Dai, Nagendran Ramalingam, John F Crary, Robert E Burke, Lloyd A Greene, Oren A Lev. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Experimental neurology. vol 303. 2018-12-20. PMID:29432724. |
we further demonstrated that guanabenz attenuates 6-hydroxydopamine (6-ohda) induced cell death of differentiated pc12 cells and primary ventral midbrain dopaminergic neurons in culture, and of dopaminergic neurons in the substantia nigra of mice. |
2018-12-20 |
2023-08-13 |
mouse |
| Satoshi Okawa, Carmen Saltó, Srikanth Ravichandran, Shanzheng Yang, Enrique M Toledo, Ernest Arenas, Antonio Del So. Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift. Nature communications. vol 9. issue 1. 2018-12-17. PMID:29968757. |
finally, transsyn predictions enable experimental conversion of human hindbrain neuroepithelial cells into medial floor plate midbrain progenitors, capable of rapidly differentiating into dopaminergic neurons. |
2018-12-17 |
2023-08-13 |
human |
| Cathy C Y Huang, Tengfei Ma, Emily A Roltsch Hellard, Xuehua Wang, Amutha Selvamani, Jiayi Lu, Farida Sohrabji, Jun Wan. Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats. Scientific reports. vol 7. issue 1. 2018-12-12. PMID:28566754. |
in addition, glutamatergic inputs onto dms d1-neurons was potentiated, whereas gabaergic inputs onto dms-projecting midbrain dopaminergic neurons was suppressed. |
2018-12-12 |
2023-08-13 |
rat |
| L Stertz, V Contreras-Shannon, N Monroy-Jaramillo, J Sun, C Walss-Bas. BACE1-Deficient Mice Exhibit Alterations in Immune System Pathways. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28004339. |
genetic deletion of bace1 leads to behavioral alterations and affects midbrain dopaminergic signaling and memory processes. |
2018-12-11 |
2023-08-13 |
mouse |
| Bo Zhou, Min Wen, Xin Lin, Yun-Hua Chen, Yun Gou, Yong Li, Yi Zhang, Hong-Wei Li, Lei Tan. Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine. Neurotoxicity research. vol 33. issue 4. 2018-12-11. PMID:29019159. |
the results of western blot indicated that alpha lipoamide significantly restored the number of dopaminergic neurons in midbrain and substantially recovered the balance between mitochondrial fission, fusion, and transport. |
2018-12-11 |
2023-08-13 |
Not clear |
| M Zuberek, T M Stępkowski, M Kruszewski, A Grzela. Exposure of human neurons to silver nanoparticles induces similar pattern of ABC transporters gene expression as differentiation: Study on proliferating and post-mitotic LUHMES cells. Mechanisms of ageing and development. vol 171. 2018-12-11. PMID:29486223. |
the lund human mesencephalic (luhmes) cell line originated from mesencephalon of 8-week human foetus is a renowned in vitro model of human dopaminergic neurons. |
2018-12-11 |
2023-08-13 |
human |
| Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmber. A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29581424. |
here, using a strategy that allows for chip-seq combined with rna-seq in small neuronal populations in vivo, we present a comparative analysis of permissive and repressive histone modifications in adult midbrain dopaminergic neurons, raphe nuclei serotonergic neurons, and embryonic neural progenitors. |
2018-12-11 |
2023-08-13 |
Not clear |
| Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmber. A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29581424. |
furthermore, we utilize the map generated by our analysis to show that the transcriptional response of midbrain dopaminergic neurons following 6-ohda or methamphetamine injection is characterized by increased expression of genes with promoters dually marked by h3k4me3/h3k27me3. |
2018-12-11 |
2023-08-13 |
Not clear |
| James D Howard, Thorsten Kahn. Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29686225. |
there is general consensus that dopaminergic midbrain neurons signal reward prediction errors, computed as the difference between expected and received reward value. |
2018-12-11 |
2023-08-13 |
human |
| Xiaolu Tang, Luyan Jiao, Meige Zheng, Yan Yan, Qi Nie, Ting Wu, Xiaomei Wan, Guofeng Zhang, Yonglin Li, Song Wu, Bin Jiang, Huaibin Cai, Pingyi Xu, Jinhai Duan, Xian Li. Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. Neuroscience. vol 373. 2018-11-26. PMID:29337233. |
in this study, we examined motor functions and analyzed several proteins implicated in the maintenance of midbrain dopaminergic (da) neurons (mdans) function of adult and aged tau |
2018-11-26 |
2023-08-13 |
mouse |
| Chi-Fen Chuang, Chen-Wei Wu, Ying Weng, Pei-San Hu, Shin-Rung Yeh, Yen-Chung Chan. High-Frequency Stimulation of the Subthalamic Nucleus Activates Motor Cortex Pyramidal Tract Neurons by a Process Involving Local Glutamate, GABA and Dopamine Receptors in Hemi-Parkinsonian Rats. The Chinese journal of physiology. vol 61. issue 2. 2018-11-26. PMID:29590745. |
rats, which had the midbrain dopaminergic neurons partially depletedunilaterally, called the hemi-parkinsonian rats, were used as a study model. |
2018-11-26 |
2023-08-13 |
rat |
| Elizabeth J Paik, Alison L O'Neil, Shi-Yan Ng, Chicheng Sun, Lee L Rubi. Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture. Scientific reports. vol 8. issue 1. 2018-11-20. PMID:29339826. |
human embryonic stem cells (escs) and induced pluripotent stem cells (ipscs) can provide sources for midbrain dopaminergic (mda) neural progenitors (npcs) for cell therapy to treat parkinson's disease (pd) patients. |
2018-11-20 |
2023-08-13 |
human |
| Ahmet Özdemir, Belgin Sever, Mehlika Dilek Altıntop, Elif Kaya Tilki, Miriş Dikme. Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-11-12. PMID:30150574. |
parkinson's disease (pd) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. |
2018-11-12 |
2023-08-13 |
Not clear |
| Xiao-Yu Cheng, Si-Yue Li, Cheng-Jie Mao, Mei-Xia Wang, Jing Chen, Fen Wang, Guang-Hui Wang, Wen-Bin Deng, Xiao-Kang Li, Chun-Feng Li. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. vol 371. 2018-11-09. PMID:29196028. |
the ablation of srf renders the midbrain dopaminergic (da) neurons vulnerable to 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced neurotoxicity, however, the underlying mechanisms remain poorly understood. |
2018-11-09 |
2023-08-13 |
rat |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
these results have provided potential circuit-level biomarkers of depression in pd, and suggested that resting state functional connectivity of midbrain dopaminergic nuclei may be useful for understanding the underlying pathology in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Bo Fu, Xie-Chuan Weng, Jing Wang, Tao Huang, Bin Wang, Shi-de Lin, Shao-Jun Li. [The impact of electrophysiology of central dopaminergic neurons and the depression-state induced by chronic neuropathic pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 5. 2018-10-18. PMID:29931842. |
to explore the underlying electrophysiological mechanism of depression induced by chronic pain in dopaminergic neurons in midbrain ventral tegmental area (vta) of rats. |
2018-10-18 |
2023-08-13 |
rat |