| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaolai Zhou, Björn Spitta. Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro. Neurotoxicity research. vol 33. issue 4. 2019-03-20. PMID:29188488. |
lipopolysaccharide-induced microglia activation promotes the survival of midbrain dopaminergic neurons in vitro. |
2019-03-20 |
2023-08-13 |
Not clear |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
preclinical studies have revealed that specific mglur subtypes mediate significant neuroprotective effects that reduce toxin-induced midbrain dopaminergic neuronal death in animal models of pd. |
2019-03-14 |
2023-08-13 |
human |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
it is noteworthy that these protective effects extend beyond midbrain dopaminergic neurons to include other monoaminergic cell groups for some mglurs. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
however, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. |
2019-03-14 |
2023-08-13 |
human |
| Kyle Denton, Yongchao Mou, Chong-Chong Xu, Dhruvi Shah, Jaerak Chang, Craig Blackstone, Xue-Jun L. Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias. Human molecular genetics. vol 27. issue 14. 2019-03-12. PMID:29726929. |
in patient ipsc-derived telencephalic glutamatergic and midbrain dopaminergic neurons, neurite number, length and branching are significantly reduced, recapitulating disease-specific phenotypes. |
2019-03-12 |
2023-08-13 |
Not clear |
| Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Pen. Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 118. issue 1 Pt 3. 2019-03-12. PMID:30031602. |
valproate is protective against 6-ohda-induced dopaminergic neurodegeneration in rodent midbrain: a potential role of bdnf up-regulation. |
2019-03-12 |
2023-08-13 |
Not clear |
| Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi Kawas. Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson's Disease Model Rats. Neuroscience. vol 386. 2019-03-11. PMID:29932984. |
although recent progress in the use of human ips cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases. |
2019-03-11 |
2023-08-13 |
human |
| Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F Gorio, Massimiliano Mazza, Anna Maria Di Giuli. Counteracting neuroinflammation in experimental Parkinson's disease favors recovery of function: effects of Er-NPCs administration. Journal of neuroinflammation. vol 15. issue 1. 2019-03-11. PMID:30501635. |
parkinson's disease (pd) is the second most common neurodegenerative disease, presenting with midbrain dopaminergic neurons degeneration. |
2019-03-11 |
2023-08-13 |
Not clear |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
local field potentials reflect dopaminergic and non-dopaminergic activities within the primate midbrain. |
2019-03-11 |
2023-08-13 |
monkey |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
together, lfps provide novel insights into the multidimensional processing of reward information subserved by dopaminergic and other components of the midbrain. |
2019-03-11 |
2023-08-13 |
monkey |
| Bianca Marchett. Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 19. issue 12. 2019-03-08. PMID:30477246. |
this review highlights a wnt/β-catenin/glial connection in parkinson's disease (pd), the most common movement disorder characterized by the selective death of midbrain dopaminergic (mdaergic) neuronal cell bodies in the subtantia nigra pars compacta (snpc) and gliosis. |
2019-03-08 |
2023-08-13 |
mouse |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
furthermore, nav1.3 was not only expressed in th-positive dopaminergic neurons of the ipsilateral and contralateral sn, but also in nestin-positive neural progenitor cells surrounding the ipsilateral sn and the midline region adjacent to the ipsilateral sn in the midbrain at 49 days postlesion. |
2019-03-07 |
2023-08-13 |
rat |
| Ima Trempler, Ellen Binder, Nadiya El-Sourani, Patrick Schiffler, Jan-Gerd Tenberge, Anne-Marike Schiffer, Gereon R Fink, Ricarda I Schubot. Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson's disease. Brain structure & function. vol 223. issue 5. 2019-02-27. PMID:29374792. |
parkinson's disease (pd), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. |
2019-02-27 |
2023-08-13 |
human |
| Indrani Datta, Kavina Ganapathy, Rema Razdan, Ramesh Bhond. Location and Number of Astrocytes Determine Dopaminergic Neuron Survival and Function Under 6-OHDA Stress Mediated Through Differential BDNF Release. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:28965325. |
however, striking differences were observed in dopaminergic neuronal (th) cell survival in the presence of midbrain astrocytes in comparison to forebrain and hindbrain astrocytes at all seeding numbers. |
2019-02-26 |
2023-08-13 |
Not clear |
| Yan-Hua Ren, Xue-Yuan Niu, Hou-Ju Huang, Xiao-Di Hao, Peng-Xiang Wang, Yi-Li Chi, Yu-Qiang Ding, Min Lia. Dopamine neuron loss by selective deletion of autophagy-related gene 5 is not exacerbated by MPTP toxicity in midbrain. Neuroscience letters. vol 675. 2019-02-22. PMID:29175031. |
parkinson's disease (pd) is a progressive neurological disease, one of the pathological characteristics is a gradual loss of midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta (snpc). |
2019-02-22 |
2023-08-13 |
mouse |
| Qiu T Ruan, Neema Yazdani, Jacob A Beierle, Kathryn M Hixson, Kristen E Hokenson, Daniel J Apicco, Kimberly P Luttik, Karen Zheng, Brandon F Maziuk, Peter E A Ash, Karen K Szumlinski, Shelley J Russek, Benjamin Wolozin, Camron D Bryan. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neuroscience letters. vol 684. 2019-02-20. PMID:30003938. |
methamphetamine initiates post-synaptic d1 dopamine receptor signaling indirectly by binding to pre-synaptic dopamine transporters and vesicular monoamine transporters of midbrain dopaminergic neurons which triggers reverse transport and accumulation of dopamine at the synapse. |
2019-02-20 |
2023-08-13 |
rat |
| Yujung Chang, Junsang Yoo, Hongwon Kim, Hi-Joon Park, Songhee Jeon, Jongpil Ki. Salusin-β mediate neuroprotective effects for Parkinson's disease. Biochemical and biophysical research communications. vol 503. issue 3. 2019-02-18. PMID:30017195. |
importantly, intranasal administration of salusin-β in a pd mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. |
2019-02-18 |
2023-08-13 |
mouse |
| Anna O Ermakova, Franziska Knolle, Azucena Justicia, Edward T Bullmore, Peter B Jones, Trevor W Robbins, Paul C Fletcher, Graham K Murra. Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29748629. |
anova revealed significant (p < 0.05 family-wise error corrected) prediction-error signalling differences between groups in the dopaminergic midbrain and right middle frontal gyrus (dorsolateral prefrontal cortex, dlpfc). |
2019-02-14 |
2023-08-13 |
human |
| Ji Young Kim, Jae Souk Lee, Hyun Sub Hwang, Dongjin R Lee, Chul-Yong Park, Sung Jun Jung, Young Rang You, Dae-Sung Kim, Dong-Wook Ki. Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells. Experimental & molecular medicine. vol 50. issue 4. 2019-02-11. PMID:29650976. |
activating wnt signal has been a strategy for differentiating human pluripotent stem cells (pscs) into midbrain dopaminergic (da) neurons; however, the underlying molecular mechanism(s) of how the wnt signal drives posterior fate remained unclear. |
2019-02-11 |
2023-08-13 |
human |