| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martina Pfeffer, Zuzana Zimmermann, Suzana Gispert, Georg Auburger, Horst-Werner Korf, Charlotte von Gal. Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein. International journal of molecular sciences. vol 19. issue 6. 2018-10-17. PMID:29865270. |
pd is characterized by a progressive degeneration of the dorsal vagal nucleus and midbrain dopaminergic neurons together with an imbalance of many other neurotransmitters. |
2018-10-17 |
2023-08-13 |
mouse |
| Maroof M Adil, Gonçalo M C Rodrigues, Rishikesh U Kulkarni, Antara T Rao, Nicole E Chernavsky, Evan W Miller, David V Schaffe. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific reports. vol 7. 2018-10-15. PMID:28091566. |
efficient generation of hpsc-derived midbrain dopaminergic neurons in a fully defined, scalable, 3d biomaterial platform. |
2018-10-15 |
2023-08-13 |
rat |
| Maroof M Adil, Gonçalo M C Rodrigues, Rishikesh U Kulkarni, Antara T Rao, Nicole E Chernavsky, Evan W Miller, David V Schaffe. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific reports. vol 7. 2018-10-15. PMID:28091566. |
for example, there have been major recent advances in the generation of midbrain dopaminergic (mda) neurons from stem cells for parkinson's disease (pd) therapy; however, production of these cells typically involves undefined components and difficult to scale 2d culture formats. |
2018-10-15 |
2023-08-13 |
rat |
| Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hami. Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864896. |
rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (sn) of midbrain producing parkinsonism. |
2018-10-15 |
2023-08-13 |
rat |
| Md Solayman, Md Asiful Islam, Fahmida Alam, Md Ibrahim Khalil, Mohammad Amjad Kamal, Siew Hua Ga. Natural Products Combating Neurodegeneration: Parkinson's Disease. Current drug metabolism. vol 18. issue 1. 2018-10-01. PMID:27396919. |
parkinson's disease (pd) is characterized by neurodegeneration and a progressive functional impairment of the midbrain nigral dopaminergic neurons. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hardy J Rideout, Diane B R. LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives. Advances in neurobiology. vol 14. 2018-09-25. PMID:28353285. |
however, the mechanism(s) by which expression of mutant forms of lrrk2 lead to the death of dopaminergic neurons of the ventral midbrain remains largely uncharacterized. |
2018-09-25 |
2023-08-13 |
Not clear |
| Hardy J Rideout, Diane B R. LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives. Advances in neurobiology. vol 14. 2018-09-25. PMID:28353285. |
however, since the expression of lrrk2 is comparatively quite low in ventral midbrain dopaminergic neurons, the possibility exists that non-cell autonomous signaling also contributes to the loss of these neurons. |
2018-09-25 |
2023-08-13 |
Not clear |
| Aliya Iftikhar Sarwa. Trazodone and Parkinsonism: The Link Strengthens. Clinical neuropharmacology. vol 41. issue 3. 2018-09-13. PMID:29634584. |
although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. |
2018-09-13 |
2023-08-13 |
Not clear |
| Bumpei Samata, Daisuke Doi, Kaneyasu Nishimura, Tetsuhiro Kikuchi, Akira Watanabe, Yoshimasa Sakamoto, Jungo Kakuta, Yuichi Ono, Jun Takahash. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nature communications. vol 7. 2018-09-05. PMID:27739432. |
purification of functional human es and ipsc-derived midbrain dopaminergic progenitors using lrtm1. |
2018-09-05 |
2023-08-13 |
human |
| Bumpei Samata, Daisuke Doi, Kaneyasu Nishimura, Tetsuhiro Kikuchi, Akira Watanabe, Yoshimasa Sakamoto, Jungo Kakuta, Yuichi Ono, Jun Takahash. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nature communications. vol 7. 2018-09-05. PMID:27739432. |
human induced pluripotent stem cells (ipscs) can provide a promising source of midbrain dopaminergic (mda) neurons for cell replacement therapy for parkinson's disease (pd). |
2018-09-05 |
2023-08-13 |
human |
| Shuhei Takahashi, Akinori Hisatsune, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuk. Polysulfide protects midbrain dopaminergic neurons from MPP Journal of pharmacological sciences. vol 137. issue 1. 2018-09-05. PMID:29709269. |
polysulfide protects midbrain dopaminergic neurons from mpp polysulfides are endogenous sulfur-containing molecular species that may regulate various cellular functions. |
2018-09-05 |
2023-08-13 |
rat |
| G I McNamara, B A Davis, M Browne, T Humby, J W Dalley, J Xia, R M John, A R Isle. Dopaminergic and behavioural changes in a loss-of-imprinting model of Cdkn1c. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857482. |
however, cdkn1c also plays an important role in the brain, being key to the appropriate proliferation and differentiation of midbrain dopaminergic neurons. |
2018-08-30 |
2023-08-13 |
Not clear |
| Francesco Rigoli, Karl J Friston, Raymond J Dola. Neural processes mediating contextual influences on human choice behaviour. Nature communications. vol 7. 2018-08-27. PMID:27535770. |
these findings suggest that context-sensitive choice is driven by a brain circuit involving hippocampus and dopaminergic midbrain. |
2018-08-27 |
2023-08-13 |
human |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Hanna Oh-Descher, Jeffrey M Beck, Silvia Ferrari, Marc A Sommer, Tobias Egne. Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration. NeuroImage. vol 162. 2018-07-25. PMID:28882633. |
this strategic change in decision-making was associated with an increased involvement of the dopaminergic midbrain, striatum, thalamus, and cerebellum in representing and integrating cue values. |
2018-07-25 |
2023-08-13 |
human |
| Simone Mesman, Sonja J Krüse, Marten P Smid. Expression analyzes of early factors in midbrain differentiation programs. Gene expression patterns : GEP. vol 27. 2018-07-25. PMID:28958789. |
mesodiencephalic dopaminergic (mdda) neurons are born in the ventricular zone (vz) of the midbrain between e10 and e12. |
2018-07-25 |
2023-08-13 |
Not clear |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
using electrochemical and imaging approaches, we investigated metabolic changes in cultured primary mouse midbrain dopaminergic neurons exposed to a parkinsonian neurotoxin, 1-methyl-4-phenylpyridinium (mpp |
2018-07-25 |
2023-08-13 |
mouse |
| Cécile Moro, Napoleon Torres, Katerina Arvanitakis, Karen Cullen, Claude Chabrol, Diane Agay, Fannie Darlot, Alim-Louis Benabid, John Mitrofani. No evidence for toxicity after long-term photobiomodulation in normal non-human primates. Experimental brain research. vol 235. issue 10. 2018-07-23. PMID:28744621. |
finally, because of our interest in parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. |
2018-07-23 |
2023-08-13 |
monkey |
| Jing Ma, Cui Huang, Kun Ma, Yan-Ping Wu, Bai-Xiang Li, Yan Su. Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Molecular medicine reports. vol 16. issue 6. 2018-07-20. PMID:29152652. |
previous studies demonstrated that combined exposure to pq and mb damages dopaminergic neurons in the midbrain. |
2018-07-20 |
2023-08-13 |
rat |
| Fudong Yan, Ying Chen, Min Li, Yingqing Wang, Wenmin Zhang, Xiaochun Chen, Qinyong Y. Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease. Medicine. vol 97. issue 28. 2018-07-18. PMID:29995769. |
lewy bodies (lb) play an essential role in the development, survival, and function maintenance of midbrain dopaminergic (da) neurons in parkinson disease (pd). |
2018-07-18 |
2023-08-13 |
Not clear |