| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrique M Toledo, Daniel Gyllborg, Ernest Arena. Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease. British journal of pharmacology. vol 174. issue 24. 2018-07-17. PMID:28547771. |
wnt signalling is critically required for midbrain dopaminergic (mda) neuron development and maintenance. |
2018-07-17 |
2023-08-13 |
human |
| Loredana Leggio, Silvia Vivarelli, Francesca L'Episcopo, Cataldo Tirolo, Salvo Caniglia, Nunzio Testa, Bianca Marchetti, Nunzio Irac. microRNAs in Parkinson's Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches. International journal of molecular sciences. vol 18. issue 12. 2018-07-13. PMID:29236052. |
pd is characterized by the progressive loss of dopaminergic (daergic) neurons in the substantia nigra pars compacta (snpc) within the midbrain, accumulation of alpha-synuclein (α-syn) in lewy bodies and neurites and excessive neuroinflammation. |
2018-07-13 |
2023-08-13 |
Not clear |
| I N Abdurasulova, I V Ekimova, A V Matsulevich, A R Gazizova, V M Klimenko, Yu F Pastukho. Impairment of non-associative learning in a rat experimental model of preclinical stage of Parkinson's disease. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. vol 476. issue 1. 2018-07-09. PMID:29101619. |
this was related to degeneration of one-third of dopaminergic neurons in the ventral tegmental area of the midbrain and their axons in the dorsolateral prefrontal cortex. |
2018-07-09 |
2023-08-13 |
rat |
| Ji-Yeun Park, Seung-Nam Kim, Junsang Yoo, Jaehwan Jang, Ahreum Lee, Ju-Young Oh, Hongwon Kim, Seung Tack Oh, Seong-Uk Park, Jongpil Kim, Hi-Joon Park, Songhee Jeo. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Molecular neurobiology. vol 54. issue 10. 2018-07-02. PMID:27844281. |
we also investigated whether mch has a beneficial role in dopaminergic neuronal protection in vitro primary midbrain and human neuronal cultures and in vivo mptp-induced, pitx3 |
2018-07-02 |
2023-08-13 |
mouse |
| Cheng Xue Du, Jian Liu, Yuan Guo, Li Zhang, Qiao Jun Zhan. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience letters. vol 662. 2018-06-29. PMID:29054431. |
the lateral habenula (lhb) is an important structure involved in various brain functions, because it controls the activity of dopaminergic and serotonergic systems in the midbrain. |
2018-06-29 |
2023-08-13 |
rat |
| Sophie Khazanov, Yael Paz, Amit Hefetz, Ben J Gonzales, Yaara Netser, Abed A Mansour, Nissim Ben-Ari. Floor plate descendants in the ependyma of the adult mouse Central Nervous System. The International journal of developmental biology. vol 61. issue 3-4-5. 2018-06-13. PMID:27528042. |
in mice lacking nato3 the floor plate cells of the spinal cord do not fully mature, whereas in the midbrain floor plate, progenitors lose some neurogenic activity, giving rise to a reduced population of dopaminergic neurons. |
2018-06-13 |
2023-08-13 |
mouse |
| Jingjing He, Zheng Xiang, Xiaoqing Zhu, Zongyong Ai, Jingsong Shen, Tianzhuang Huang, Liegang Liu, Weizhi Ji, Tianqing L. Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP Scientific reports. vol 6. 2018-06-12. PMID:27731318. |
neuroprotective effects of 7, 8-dihydroxyflavone on midbrain dopaminergic neurons in mpp parkinson's disease (pd) is one common neurodegenerative disease caused by a significant loss of midbrain dopaminergic neurons. |
2018-06-12 |
2023-08-13 |
mouse |
| Jingjing He, Zheng Xiang, Xiaoqing Zhu, Zongyong Ai, Jingsong Shen, Tianzhuang Huang, Liegang Liu, Weizhi Ji, Tianqing L. Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP Scientific reports. vol 6. 2018-06-12. PMID:27731318. |
importantly, 7, 8-dhf treatments can prevent the progressive degeneration of midbrain dopaminergic neurons by attenuating neurotoxic effects of mpp |
2018-06-12 |
2023-08-13 |
mouse |
| L M Shapoval, B S Kop'yak, O V Dmytrenko, V O Mayskiy, O P Mankivaska, V F Sagac. NO-ERGIC CONTROL OF BLOOD CIRCULATION IN THE MEDULLA OBLONGATA OF RATS WITH EXPERIMENTAL HEMIPARKINSONIZM UNDER EXPOSURE TO CONTINUOUS LIGHT. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 62. issue 6. 2018-06-12. PMID:29762971. |
the study was conducted on rats with unilateral damage to dopaminergic (da) neurons in substantia nigra of the midbrain (experimental hemiparkinsonism). |
2018-06-12 |
2023-08-13 |
rat |
| Tobias U Hauser, Eran Eldar, Raymond J Dola. Separate mesocortical and mesolimbic pathways encode effort and reward learning signals. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 35. 2018-06-11. PMID:28808037. |
we show a common mesencephalic origin for these signals evident in overlapping, but spatially dissociable, dopaminergic midbrain regions expressing both types of pe. |
2018-06-11 |
2023-08-13 |
Not clear |
| Yan Gu, Xueping Hu, Weigang Pan, Chun Yang, Lijun Wang, Yiyuan Li, Antao Che. Neural Activities Underlying the Feedback Express Salience Prediction Errors for Appetitive and Aversive Stimuli. Scientific reports. vol 6. 2018-06-06. PMID:27694920. |
the feedback-related negativity (frn), a frontocentral negative deflection after the delivery of feedback, has been found to be larger for outcomes that are worse than expected, and it reflects a reward prediction error derived from the midbrain dopaminergic projections to the anterior cingulate cortex (acc), as stated in reinforcement learning theory. |
2018-06-06 |
2023-08-13 |
Not clear |
| Melanie Feuerstein, Enaam Chleilat, Shokoufeh Khakipoor, Konstantinos Michailidis, Christian Ophoven, Eleni Rouss. Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell and tissue research. vol 370. issue 2. 2018-06-05. PMID:28799057. |
the temporal dynamic expression of sonic hedgehog (shh) and signaling during early midbrain dopaminergic (mda) neuron development is one of the key players in establishing mda progenitor diversity. |
2018-06-05 |
2023-08-13 |
mouse |
| Melanie Feuerstein, Enaam Chleilat, Shokoufeh Khakipoor, Konstantinos Michailidis, Christian Ophoven, Eleni Rouss. Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell and tissue research. vol 370. issue 2. 2018-06-05. PMID:28799057. |
moreover, we examine the expression and regulation of dopaminergic neuronal progenitor markers, midbrain dopaminergic neuronal markers and markers of the shh signaling pathway in undifferentiated and butyric acid-treated (differentiated) mn9d cells in the presence or absence of exogenous shh in vitro by rt-pcr, immunoblotting and immunocytochemistry. |
2018-06-05 |
2023-08-13 |
mouse |
| Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhar. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D NeuroImage. vol 158. 2018-06-01. PMID:28655632. |
in the present study, the normative data of dopaminergic neurotransmission functions in the midbrain, consisting of neuromelanin, dopamine synthesis, dopamine transporters and dopamine d |
2018-06-01 |
2023-08-13 |
Not clear |
| Michael S Cohen, Jesse Rissman, Mariam Hovhannisyan, Alan D Castel, Barbara J Knowlto. Free recall test experience potentiates strategy-driven effects of value on memory. Journal of experimental psychology. Learning, memory, and cognition. vol 43. issue 10. 2018-05-29. PMID:28394160. |
by another mechanism, information paired with value or reward is automatically strengthened in memory via dopaminergic projections from midbrain to hippocampus (shohamy & adcock, 2010). |
2018-05-29 |
2023-08-13 |
human |
| Rui-Fang Dong, Bing Zhang, Li-Wen Tai, Hong-Mei Liu, Fang-Kun Shi, Ning-Ning Li. The Neuroprotective Role of MiR-124-3p in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5. Journal of cellular biochemistry. vol 119. issue 1. 2018-05-29. PMID:28543594. |
parkinson's disease (pd), the second most common neurodegenerative disorder, is characterized by a progressive loss of dopaminergic neurons in the midbrain. |
2018-05-29 |
2023-08-13 |
Not clear |
| S N Suresh, Aravinda K Chavalmane, Vidyadhara Dj, Haorei Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Phalguni Anand Alladi, Ravi Manjithay. A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy. vol 13. issue 7. 2018-05-25. PMID:28350199. |
importantly, neuroprotective function of 6-bio as envisaged by immunohistology and behavior analyses in a preclinical model of pd where it induces autophagy in dopaminergic (daergic) neurons of mice midbrain to clear toxic protein aggregates suggesting that it could be a potential therapeutic candidate for protein conformational disorders. |
2018-05-25 |
2023-08-13 |
mouse |
| Sonja C Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G Kabra, Ulrich Hafen, Artem Romanov, Matthias H Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M Hölter, Daniela Vogt Weisenhorn, Paul T Pfluge. Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. vol 357. 2018-05-22. PMID:28627418. |
gpx4 was deleted from either agrp or pomc neurons in the hypothalamus, essential for metabolic homeostasis, or from dopaminergic neurons in the ventral midbrain, governing behaviors such as anxiety or voluntary movement. |
2018-05-22 |
2023-08-13 |
mouse |
| Sonja C Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G Kabra, Ulrich Hafen, Artem Romanov, Matthias H Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M Hölter, Daniela Vogt Weisenhorn, Paul T Pfluge. Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. vol 357. 2018-05-22. PMID:28627418. |
to exacerbate oxidative stress in dopaminergic neurons of the ventral midbrain, we systemically co-deleted the pd-related gene dj-1. |
2018-05-22 |
2023-08-13 |
mouse |
| Sonja C Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G Kabra, Ulrich Hafen, Artem Romanov, Matthias H Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M Hölter, Daniela Vogt Weisenhorn, Paul T Pfluge. Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. vol 357. 2018-05-22. PMID:28627418. |
moreover, gpx4 appears to constitute an important rheostat against neuronal dysfunction and pd-like symptoms in dopaminergic circuitry within the ventral midbrain. |
2018-05-22 |
2023-08-13 |
mouse |