| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengrui Li, Xiaofei Tian, Xiaoni Zhan, Baojie Wang, Mei Ding, Hao Pan. Clathrin-Dependent Uptake of Paraquat into SH-SY5Y Cells and Its Internalization into Different Subcellular Compartments. Neurotoxicity research. vol 32. issue 2. 2018-04-02. PMID:28303546. |
the herbicide paraquat (pq) is an exogenous toxin that allows the selective activation of dopaminergic neurons in the mesencephalon to induce injury and also causes its apoptosis in vitro. |
2018-04-02 |
2023-08-13 |
Not clear |
| Malin Parma. Towards stem cell based therapies for Parkinson's disease. Development (Cambridge, England). vol 145. issue 1. 2018-03-29. PMID:29311261. |
now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching. |
2018-03-29 |
2023-08-13 |
Not clear |
| Sandeep More, Dong-Kug Cho. Neuroprotective Role of Atractylenolide-I in an In Vitro and In Vivo Model of Parkinson's Disease. Nutrients. vol 9. issue 5. 2018-03-28. PMID:28468332. |
parkinson's disease (pd) is an age-related neurological disorder characterized by a loss of dopaminergic neurons within the midbrain. |
2018-03-28 |
2023-08-13 |
mouse |
| Stefanie Seiler, Stefano Di Santo, Sebastian Sahli, Lukas Andereggen, Hans Rudolf Widme. Nogo-receptor 1 antagonization in combination with neurotrophin-4/5 is not superior to single factor treatment in promoting survival and morphological complexity of cultured dopaminergic neurons. Brain research. vol 1668. 2018-03-28. PMID:28535980. |
we have previously shown that antagonization of the nogo-receptor 1 by nep1-40 promoted survival of cultured dopaminergic neurons and exposure to neurotrophin-4/5 increased dopaminergic cell densities in organotypic midbrain cultures. |
2018-03-28 |
2023-08-13 |
rat |
| Yuanzhong Xu, Yungang Lu, Pingwen Xu, Leandra R Mangieri, Elsa Isingrini, Yong Xu, Bruno Giros, Qingchun Ton. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. vol 4. issue 3. 2018-03-20. PMID:28560316. |
here, we showed that midbrain lepr neurons overlap with a subset of dopaminergic, gabaergic and glutamatergic neurons. |
2018-03-20 |
2023-08-13 |
mouse |
| Nabil El Massri, Ana P Lemgruber, Isobel J Rowe, Cécile Moro, Napoleon Torres, Florian Reinhart, Claude Chabrol, Alim-Louis Benabid, John Mitrofani. Photobiomodulation-induced changes in a monkey model of Parkinson's disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental brain research. vol 235. issue 6. 2018-03-19. PMID:28299414. |
intracranial application of red to infrared light, known also as photobiomodulation (pbm), has been shown to improve locomotor activity and to neuroprotect midbrain dopaminergic cells in rodent and monkey models of parkinson's disease. |
2018-03-19 |
2023-08-13 |
monkey |
| Karamjit Singh Dolt, Fella Hammachi, Tilo Kunat. Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations. Brain pathology (Zurich, Switzerland). vol 27. issue 4. 2018-03-16. PMID:28585381. |
there are multiple neuronal subtypes affected in pd including the midbrain dopaminergic (mda) neurons of the substantia nigra. |
2018-03-16 |
2023-08-13 |
human |
| Akihiro Mouri, Yukihiro Noda, Minae Niwa, Yurie Matsumoto, Takayoshi Mamiya, Atsumi Nitta, Kiyofumi Yamada, Shoei Furukawa, Tatsunori Iwamura, Toshitaka Nabeshim. The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behavioural brain research. vol 329. 2018-03-15. PMID:28472632. |
brain-derived neurotrophic factor (bdnf) is involved in the synaptic plasticity and neurotrophy in midbrain dopaminergic neurons. |
2018-03-15 |
2023-08-13 |
mouse |
| Akihiro Mouri, Yukihiro Noda, Minae Niwa, Yurie Matsumoto, Takayoshi Mamiya, Atsumi Nitta, Kiyofumi Yamada, Shoei Furukawa, Tatsunori Iwamura, Toshitaka Nabeshim. The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behavioural brain research. vol 329. 2018-03-15. PMID:28472632. |
these results suggest that bdnf is implicated in mdma-induced dependence and psychosis by activating the midbrain serotonergic and dopaminergic neurons. |
2018-03-15 |
2023-08-13 |
mouse |
| Takafumi Hasegawa, Naoto Sugeno, Akio Kikuchi, Toru Baba, Masashi Aok. Membrane Trafficking Illuminates a Path to Parkinson's Disease. The Tohoku journal of experimental medicine. vol 242. issue 1. 2018-03-09. PMID:28539529. |
the neuropathology of pd consists of the loss of dopaminergic neurons in the midbrain and the appearance of neuronal inclusions called lewy bodies, which contain insoluble α-synuclein, a relatively small protein originally identified in association with synaptic vesicles in the presynaptic nerve terminals. |
2018-03-09 |
2023-08-13 |
Not clear |
| Maroof M Adil, Tandis Vazin, Badriprasad Ananthanarayanan, Gonçalo M C Rodrigues, Antara T Rao, Rishikesh U Kulkarni, Evan W Miller, Sanjay Kumar, David V Schaffe. Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials. vol 136. 2018-03-06. PMID:28505596. |
engineered hydrogels increase the post-transplantation survival of encapsulated hesc-derived midbrain dopaminergic neurons. |
2018-03-06 |
2023-08-13 |
human |
| Maroof M Adil, Tandis Vazin, Badriprasad Ananthanarayanan, Gonçalo M C Rodrigues, Antara T Rao, Rishikesh U Kulkarni, Evan W Miller, Sanjay Kumar, David V Schaffe. Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials. vol 136. 2018-03-06. PMID:28505596. |
for example, following striatal transplantation of midbrain dopaminergic (mda) neurons for the treatment of parkinson's disease (pd), only 1-5% of the neurons typically survive in preclinical models and in clinical trials. |
2018-03-06 |
2023-08-13 |
human |
| Kamin Kim, Martijn L T M Müller, Nicolaas I Bohnen, Martin Sarter, Cindy Lusti. Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses. NeuroImage. vol 149. 2018-02-27. PMID:28167350. |
in simple correlation analyses, measures of midbrain dopaminergic, and both cortical and thalamic cholinergic innervation all predicted preserved signal detection under challenge. |
2018-02-27 |
2023-08-13 |
Not clear |
| Gunasingh Jeyaraj Masilamoni, Olivia Groover, Yoland Smit. Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042095. |
reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in mptp-treated parkinsonian monkeys. |
2018-02-22 |
2023-08-13 |
monkey |
| Gunasingh Jeyaraj Masilamoni, Olivia Groover, Yoland Smit. Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042095. |
there is anatomical and functional evidence that ventral midbrain dopaminergic (da) cell groups and the subthalamic nucleus (stn) receive noradrenergic innervation in rodents, but much less is known about these interactions in primates. |
2018-02-22 |
2023-08-13 |
monkey |
| Daniel C Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A Pitsillides, Kirsten Harve. Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling. Molecular neurodegeneration. vol 12. issue 1. 2018-02-22. PMID:28103901. |
this pathway is critical for the development and survival of the midbrain dopaminergic neurones typically lost in parkinson's disease. |
2018-02-22 |
2023-08-13 |
Not clear |
| Anna S Monzel, Lisa M Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M T Fleming, Silvia Bolognin, Jens C Schwambor. Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem cell reports. vol 8. issue 5. 2018-02-22. PMID:28416282. |
these human midbrain organoids contain spatially organized groups of dopaminergic neurons, which make them an attractive model for the study of parkinson's disease. |
2018-02-22 |
2023-08-13 |
human |
| Haishuang Lin, Qiang Li, Yuguo Le. Three-dimensional tissues using human pluripotent stem cell spheroids as biofabrication building blocks. Biofabrication. vol 9. issue 2. 2018-02-21. PMID:28287080. |
in this paper, we systematically measured the fusion rates of hpsc spheroids without and with differentiation toward cortical and midbrain dopaminergic neurons and found spheroids' fusion rates dropped sharply as differentiation progressed. |
2018-02-21 |
2023-08-13 |
human |
| Ping Zhong, Zhixing Hu, Houbo Jiang, Zhen Yan, Jian Fen. Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations. Cell reports. vol 19. issue 5. 2018-02-13. PMID:28467897. |
the aberrant dopaminergic regulation of presynaptic glutamatergic transmission in patient-specific ipsc-derived midbrain neurons provides a mechanistic clue to pd pathophysiology, and it demonstrates the usefulness of this model system in understanding how mutations of parkin cause movement symptoms in parkinson's disease. |
2018-02-13 |
2023-08-13 |
human |
| Carlos F Ibáñez, Jaan-Olle Andresso. Biology of GDNF and its receptors - Relevance for disorders of the central nervous system. Neurobiology of disease. vol 97. issue Pt B. 2018-02-12. PMID:26829643. |
a targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons resulted in the isolation of gdnf (glial cell line-derived neurotrophic factor) from the supernatant of a rat glial cell line in 1993. |
2018-02-12 |
2023-08-13 |
rat |