| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yamazaki, I Shiojima, I Komuro, R Nagai, Y Yazak. Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 12. issue 9. 1995-04-11. PMID:7884580. |
to elucidate the regulation of cardiac gene expression by mechanical stress and to analyse molecular mechanisms associated with the involvement of angiotensin ii (ang ii) in the development of cardiac hypertrophy and dysfunction. |
1995-04-11 |
2023-08-12 |
Not clear |
| X L Ding, C Y Zhou, Y X L. [The roles of protein kinase C and Na(+)-H+ exchange in the angiotensin II-induced hypertrophic response]. Sheng li xue bao : [Acta physiologica Sinica]. vol 46. issue 5. 1995-03-03. PMID:7846546. |
in order to study the roles of protein kinase c (pkc) and na(+)-h+ exchange in [sar1] ang ii-induced hypertrophic response, 3h-leucine incorporation into serum-free cultured neonatal rat cardiomyocytes were interfered with staurosporine, phorbol 12-myristate 13-acetate (pma) or amiloride. |
1995-03-03 |
2023-08-12 |
rat |
| X L Ding, C Y Zhou, Y X L. [The roles of protein kinase C and Na(+)-H+ exchange in the angiotensin II-induced hypertrophic response]. Sheng li xue bao : [Acta physiologica Sinica]. vol 46. issue 5. 1995-03-03. PMID:7846546. |
these results demonstrated that activation of pkc and na(+)-h+ exchange might mediate the hypertrophic response initiated by [sar1] ang ii. |
1995-03-03 |
2023-08-12 |
rat |
| B Tian, G D Gao, J Liu, Z P Cao, X L. [Role of cardiac renin-angiotensin system in swimming induced physiological myocardial hypertrophy]. Sheng li xue bao : [Acta physiologica Sinica]. vol 46. issue 5. 1995-03-03. PMID:7846553. |
to determine the contribution of cardiac renin-angiotensin system (ras) to the physiological myocardial hypertrophy induced by swimming training and the relationship between locally produced and circulating ras, both ventricular and plasma angiotensin (ang) i and ii contents, ventricular angiotensin converting enzyme (ace) and plasma renin activity (pra) were detected by means of radioimmunoassay and biochemical method. |
1995-03-03 |
2023-08-12 |
Not clear |
| Y Tian, T Balla, A J Baukal, K J Cat. Growth responses to angiotensin II in bovine adrenal glomerulosa cells. The American journal of physiology. vol 268. issue 1 Pt 1. 1995-02-28. PMID:7840171. |
the effects of angiotensin ii (ang ii) on growth responses of primary cultures of bovine adrenal glomerulosa cells were studied to explore the mechanism(s) by which ang ii leads to hyperplasia and hypertrophy of the glomerulosa layer in sodium deficiency. |
1995-02-28 |
2023-08-12 |
cattle |
| J B O'Sullivan, M J Black, J F Bertram, A Bobi. Cardiovascular hypertrophy in one-kidney, one clip renal hypertensive rats: a role for angiotensin II? Journal of hypertension. vol 12. issue 10. 1995-02-24. PMID:7836732. |
to investigate the role of angiotensin ii (ang ii) in cardiovascular hypertrophy in the goldblatt one-kidney, one clip (1-k, 1c) renal hypertensive rat. |
1995-02-24 |
2023-08-12 |
rat |
| J Sadoshima, Z Qiu, J P Morgan, S Izum. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circulation research. vol 76. issue 1. 1995-01-26. PMID:8001266. |
many hypertrophic stimuli such as angiotensin ii (ang ii) activate phospholipases through g protein-coupled receptors in cardiac myocytes. |
1995-01-26 |
2023-08-12 |
rat |
| J Sadoshima, Z Qiu, J P Morgan, S Izum. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circulation research. vol 76. issue 1. 1995-01-26. PMID:8001266. |
these results suggest that ang ii and other hypertrophic stimuli, known to act through gq protein-coupled receptors, rapidly cause tyrosine phosphorylation of several intracellular substrates through activation of tyrosine kinase and activate map kinases and rsk in cardiac myocytes as well as in cardiac fibroblasts. |
1995-01-26 |
2023-08-12 |
rat |
| J R Schelling, D J DeLuca, M Konieczkowski, R Marzec, J R Sedor, G R Dubyak, S L Lina. Glucocorticoid uncoupling of antiogensin II-dependent phospholipase C activation in rat vascular smooth muscle cells. Kidney international. vol 46. issue 3. 1995-01-18. PMID:7996788. |
finally, prolonged incubation with dexamethasone and ang ii had additive effects on vsmc hypertrophy. |
1995-01-18 |
2023-08-12 |
rat |
| J R Schelling, D J DeLuca, M Konieczkowski, R Marzec, J R Sedor, G R Dubyak, S L Lina. Glucocorticoid uncoupling of antiogensin II-dependent phospholipase C activation in rat vascular smooth muscle cells. Kidney international. vol 46. issue 3. 1995-01-18. PMID:7996788. |
in conclusion, glucocorticoids directly altered ang ii function in vsmc by causing increased ang ii receptor number, ang ii receptor/plc uncoupling, and enhanced ang ii-dependent hypertrophy. |
1995-01-18 |
2023-08-12 |
rat |
| H S Sharma, H A van Heugten, M A Goedbloed, P D Verdouw, J M Lamer. Angiotensin II induced expression of transcription factors precedes increase in transforming growth factor-beta 1 mRNA in neonatal cardiac fibroblasts. Biochemical and biophysical research communications. vol 205. issue 1. 1995-01-17. PMID:7999008. |
angiotensin ii (ang ii), a potent vasoconstricting peptide, may act as a growth factor for cardiac muscle cells and induce hypertrophy. |
1995-01-17 |
2023-08-12 |
rat |
| H S Sharma, H A van Heugten, M A Goedbloed, P D Verdouw, J M Lamer. Angiotensin II induced expression of transcription factors precedes increase in transforming growth factor-beta 1 mRNA in neonatal cardiac fibroblasts. Biochemical and biophysical research communications. vol 205. issue 1. 1995-01-17. PMID:7999008. |
our results indicate that ang ii transiently stimulates the expression of transcription factors, which may up-regulate tgf-beta 1, that in turn could contribute to the process of myocardial extra-cellular matrix remodeling in hypertrophy. |
1995-01-17 |
2023-08-12 |
rat |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
relevant roles of protein kinase c. thromboxane a2 (txa2) and angiotensin ii (ang ii) stimulate vascular smooth muscle hypertrophy by upregulating endogenous synthesis of basic fibroblast growth factor (bfgf). |
1994-11-21 |
2023-08-12 |
Not clear |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
to clarify the role of pkc in vasoconstrictor-stimulated vsmc production of bfgf and hypertrophy, pkc was down-regulated by prolonged exposure to pma or was inhibited with calphostin c or staurosporine before the addition of txa2 or ang ii. |
1994-11-21 |
2023-08-12 |
Not clear |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
pkc inhibition prevented txa2-stimulated and ang ii--stimulated vsmc hypertrophy without attenuating the observed increase in bfgf expression. |
1994-11-21 |
2023-08-12 |
Not clear |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
the role of angiotensin ii (ang ii) in the development of isoproterenol (iso)-induced cardiac hypertrophy was examined in rats. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
the ang ii receptor blocker losartan (los) did not significantly decrease the hypertrophic response to iso. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
ang ii, injected continuously at a subpressor dose that did not affect heart weight when given alone, inhibited reversal of cardiac hypertrophy when given after cessation of iso. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
we conclude that endogenous ang ii has a major function in maintaining iso-induced cardiac hypertrophy but does not mediate its induction. |
1994-11-18 |
2023-08-12 |
rat |
| R Morishita, G H Gibbons, K E Ellison, W Lee, L Zhang, H Yu, Y Kaneda, T Ogihara, V J Dza. Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. The Journal of clinical investigation. vol 94. issue 3. 1994-10-13. PMID:8083382. |
however, it is still unclear if ang ii exerts a direct effect on vascular hypertrophy in vivo independent of its effect on blood pressure. |
1994-10-13 |
2023-08-12 |
human |