| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H S Sharma, H A van Heugten, M A Goedbloed, P D Verdouw, J M Lamer. Angiotensin II induced expression of transcription factors precedes increase in transforming growth factor-beta 1 mRNA in neonatal cardiac fibroblasts. Biochemical and biophysical research communications. vol 205. issue 1. 1995-01-17. PMID:7999008. |
our results indicate that ang ii transiently stimulates the expression of transcription factors, which may up-regulate tgf-beta 1, that in turn could contribute to the process of myocardial extra-cellular matrix remodeling in hypertrophy. |
1995-01-17 |
2023-08-12 |
rat |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
relevant roles of protein kinase c. thromboxane a2 (txa2) and angiotensin ii (ang ii) stimulate vascular smooth muscle hypertrophy by upregulating endogenous synthesis of basic fibroblast growth factor (bfgf). |
1994-11-21 |
2023-08-12 |
Not clear |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
to clarify the role of pkc in vasoconstrictor-stimulated vsmc production of bfgf and hypertrophy, pkc was down-regulated by prolonged exposure to pma or was inhibited with calphostin c or staurosporine before the addition of txa2 or ang ii. |
1994-11-21 |
2023-08-12 |
Not clear |
| S Ali, M W Becker, M G Davis, G W Dor. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C. Circulation research. vol 75. issue 5. 1994-11-21. PMID:7923629. |
pkc inhibition prevented txa2-stimulated and ang ii--stimulated vsmc hypertrophy without attenuating the observed increase in bfgf expression. |
1994-11-21 |
2023-08-12 |
Not clear |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
the role of angiotensin ii (ang ii) in the development of isoproterenol (iso)-induced cardiac hypertrophy was examined in rats. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
the ang ii receptor blocker losartan (los) did not significantly decrease the hypertrophic response to iso. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
ang ii, injected continuously at a subpressor dose that did not affect heart weight when given alone, inhibited reversal of cardiac hypertrophy when given after cessation of iso. |
1994-11-18 |
2023-08-12 |
rat |
| E Golomb, Z A Abassi, G Cuda, M Stylianou, V R Panchal, D Trachewsky, H R Keise. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. The American journal of physiology. vol 267. issue 4 Pt 2. 1994-11-18. PMID:7524366. |
we conclude that endogenous ang ii has a major function in maintaining iso-induced cardiac hypertrophy but does not mediate its induction. |
1994-11-18 |
2023-08-12 |
rat |
| R Morishita, G H Gibbons, K E Ellison, W Lee, L Zhang, H Yu, Y Kaneda, T Ogihara, V J Dza. Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. The Journal of clinical investigation. vol 94. issue 3. 1994-10-13. PMID:8083382. |
however, it is still unclear if ang ii exerts a direct effect on vascular hypertrophy in vivo independent of its effect on blood pressure. |
1994-10-13 |
2023-08-12 |
human |
| J J Lopez, B H Lorell, J R Ingelfinger, E O Weinberg, H Schunkert, D Diamant, S S Tan. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. The American journal of physiology. vol 267. issue 2 Pt 2. 1994-09-21. PMID:8067441. |
to determine distribution and function of cardiac angiotensin (ang) ii receptor at1 and at2 subtypes in left ventricular (lv) hypertrophy (lvh), ang ii (10(-8) m) was infused into isolated rat hearts with hypertrophy from aortic banding and into sham-operated controls. |
1994-09-21 |
2023-08-12 |
rat |
| J J Lopez, B H Lorell, J R Ingelfinger, E O Weinberg, H Schunkert, D Diamant, S S Tan. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. The American journal of physiology. vol 267. issue 2 Pt 2. 1994-09-21. PMID:8067441. |
nonetheless, the at1 subtype mediates the effects of ang ii on coronary tone and diastolic dysfunction in pressure-overload hypertrophy. |
1994-09-21 |
2023-08-12 |
rat |
| S Miyata, T Haned. Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024006. |
primary cultures of neonatal cardiac myocytes were used to determine the identity of second messengers that are involved in angiotensin ii (ang ii) receptor-mediated effects on cardiac hypertrophy and the type of ang ii receptor that is involved in ang ii-induced cell growth. |
1994-08-02 |
2023-08-12 |
rat |
| S Miyata, T Haned. Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024006. |
these studies demonstrate that ang ii-induced hypertrophic growth is, at least in part, mediated through at1 receptors. |
1994-08-02 |
2023-08-12 |
rat |
| H A Rockman, S P Wachhorst, L Mao, J Ros. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024008. |
ang ii receptor blockade prevents ventricular hypertrophy and anf gene expression with pressure overload in mice. |
1994-08-02 |
2023-08-12 |
mouse |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
previously, we reported that an orally active angiotensin ii (ang ii) receptor antagonist losartan induces regression of left ventricular hypertrophy with reduction in the tissue ang ii contents in spontaneously hypertensive rats (shr). |
1994-07-05 |
2023-08-12 |
human |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
to further address the role of the cardiac renin-angiotensin system in the pathophysiology of hypertensive left ventricular hypertrophy, we examined the effects of tcv-116, a newly developed, highly specific nonpeptide ang ii receptor antagonist, on cardiac hypertrophy and the tissue angiotensin i (ang i) and ang ii, as well as plasma renin activity (pra) and ang ii, were determined. |
1994-07-05 |
2023-08-12 |
human |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
these results not only further support the view that cardiac ang ii, rather than circulating ang ii, plays an important role in the pathophysiology of left ventricular hypertrophy of this animal model of human hypertension, but imply also that tcv-116 induces regression of hypertensive left ventricular hypertrophy through suppression of the tissue renin-angiotensin system. |
1994-07-05 |
2023-08-12 |
human |
| K K Griendling, C A Minieri, J D Ollerenshaw, R W Alexande. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation research. vol 74. issue 6. 1994-06-23. PMID:8187280. |
these observations suggest that ang ii specifically activates enzyme systems that promote superoxide generation and raise the possibility that these pathways function as second messengers for long-term responses, such as hypertrophy or hyperplasia. |
1994-06-23 |
2023-08-12 |
Not clear |
| M Kojima, I Shiojima, T Yamazaki, I Komuro, Z Zou, Y Wang, T Mizuno, K Ueki, K Tobe, T Kadowak. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. vol 89. issue 5. 1994-06-14. PMID:8181146. |
to elucidate the role of ras in the progression of cardiac hypertrophy, we evaluated the effect of an ang ii receptor antagonist on lvh in spontaneously hypertensive rats (shrs) and investigated the molecular mechanisms by which antagonizing ang ii receptors reduces cell hypertrophy of myocytes using the in vitro model of mechanical stretch. |
1994-06-14 |
2023-08-12 |
rat |
| D A Goldfar. The renin-angiotensin system. New concepts in regulation of blood pressure and renal function. The Urologic clinics of North America. vol 21. issue 2. 1994-06-07. PMID:8178386. |
ang ii is now considered a growth promoter in cardiovascular tissues, and the resultant vascular hypertrophy is an important contributor to the maintenance of hypertension. |
1994-06-07 |
2023-08-12 |
Not clear |