| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Lopez, B H Lorell, J R Ingelfinger, E O Weinberg, H Schunkert, D Diamant, S S Tan. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. The American journal of physiology. vol 267. issue 2 Pt 2. 1994-09-21. PMID:8067441. |
to determine distribution and function of cardiac angiotensin (ang) ii receptor at1 and at2 subtypes in left ventricular (lv) hypertrophy (lvh), ang ii (10(-8) m) was infused into isolated rat hearts with hypertrophy from aortic banding and into sham-operated controls. |
1994-09-21 |
2023-08-12 |
rat |
| J J Lopez, B H Lorell, J R Ingelfinger, E O Weinberg, H Schunkert, D Diamant, S S Tan. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. The American journal of physiology. vol 267. issue 2 Pt 2. 1994-09-21. PMID:8067441. |
nonetheless, the at1 subtype mediates the effects of ang ii on coronary tone and diastolic dysfunction in pressure-overload hypertrophy. |
1994-09-21 |
2023-08-12 |
rat |
| S Miyata, T Haned. Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024006. |
primary cultures of neonatal cardiac myocytes were used to determine the identity of second messengers that are involved in angiotensin ii (ang ii) receptor-mediated effects on cardiac hypertrophy and the type of ang ii receptor that is involved in ang ii-induced cell growth. |
1994-08-02 |
2023-08-12 |
rat |
| S Miyata, T Haned. Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024006. |
these studies demonstrate that ang ii-induced hypertrophic growth is, at least in part, mediated through at1 receptors. |
1994-08-02 |
2023-08-12 |
rat |
| H A Rockman, S P Wachhorst, L Mao, J Ros. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. The American journal of physiology. vol 266. issue 6 Pt 2. 1994-08-02. PMID:8024008. |
ang ii receptor blockade prevents ventricular hypertrophy and anf gene expression with pressure overload in mice. |
1994-08-02 |
2023-08-12 |
mouse |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
previously, we reported that an orally active angiotensin ii (ang ii) receptor antagonist losartan induces regression of left ventricular hypertrophy with reduction in the tissue ang ii contents in spontaneously hypertensive rats (shr). |
1994-07-05 |
2023-08-12 |
human |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
to further address the role of the cardiac renin-angiotensin system in the pathophysiology of hypertensive left ventricular hypertrophy, we examined the effects of tcv-116, a newly developed, highly specific nonpeptide ang ii receptor antagonist, on cardiac hypertrophy and the tissue angiotensin i (ang i) and ang ii, as well as plasma renin activity (pra) and ang ii, were determined. |
1994-07-05 |
2023-08-12 |
human |
| K Mizuno, S Niimura, K Katoh, S Fukuch. TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. Life sciences. vol 54. issue 25. 1994-07-05. PMID:8201847. |
these results not only further support the view that cardiac ang ii, rather than circulating ang ii, plays an important role in the pathophysiology of left ventricular hypertrophy of this animal model of human hypertension, but imply also that tcv-116 induces regression of hypertensive left ventricular hypertrophy through suppression of the tissue renin-angiotensin system. |
1994-07-05 |
2023-08-12 |
human |
| K K Griendling, C A Minieri, J D Ollerenshaw, R W Alexande. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation research. vol 74. issue 6. 1994-06-23. PMID:8187280. |
these observations suggest that ang ii specifically activates enzyme systems that promote superoxide generation and raise the possibility that these pathways function as second messengers for long-term responses, such as hypertrophy or hyperplasia. |
1994-06-23 |
2023-08-12 |
Not clear |
| M Kojima, I Shiojima, T Yamazaki, I Komuro, Z Zou, Y Wang, T Mizuno, K Ueki, K Tobe, T Kadowak. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. vol 89. issue 5. 1994-06-14. PMID:8181146. |
to elucidate the role of ras in the progression of cardiac hypertrophy, we evaluated the effect of an ang ii receptor antagonist on lvh in spontaneously hypertensive rats (shrs) and investigated the molecular mechanisms by which antagonizing ang ii receptors reduces cell hypertrophy of myocytes using the in vitro model of mechanical stretch. |
1994-06-14 |
2023-08-12 |
rat |
| D A Goldfar. The renin-angiotensin system. New concepts in regulation of blood pressure and renal function. The Urologic clinics of North America. vol 21. issue 2. 1994-06-07. PMID:8178386. |
ang ii is now considered a growth promoter in cardiovascular tissues, and the resultant vascular hypertrophy is an important contributor to the maintenance of hypertension. |
1994-06-07 |
2023-08-12 |
Not clear |
| D A Goldfar. The renin-angiotensin system. New concepts in regulation of blood pressure and renal function. The Urologic clinics of North America. vol 21. issue 2. 1994-06-07. PMID:8178386. |
ang ii also plays a role in the kidney, not only as a regulator of hemodynamics, but in the development of structural changes (hypertrophy, sclerosis), which are important in the pathogenesis of a variety of renal disorders. |
1994-06-07 |
2023-08-12 |
Not clear |
| H San. [Effect of angiotensin II on collagen metabolism in cultured rat cardiac fibroblasts: its relation to cardiac hypertrophy]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 69. issue 1. 1994-04-04. PMID:8119655. |
thus, ang ii may play an important role in collagen accumulation in hypertensive cardiac hypertrophy. |
1994-04-04 |
2023-08-12 |
rat |
| S W Rabki. Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 22 Suppl 6. 1994-03-08. PMID:7508059. |
angiotensin ii (ang)-receptor stimulation with ang ii and muscarinic-receptor stimulation with carbachol, accentuate camp stimulation in cardiac hypertrophy, whereas the reverse or inhibition was noted in normal myocardium. |
1994-03-08 |
2023-08-12 |
rat |
| M L Burgess, W E Carver, L Terracio, S P Wilson, M A Wilson, T K Bor. Integrin-mediated collagen gel contraction by cardiac fibroblasts. Effects of angiotensin II. Circulation research. vol 74. issue 2. 1994-02-28. PMID:8293568. |
angiotensin ii (ang ii), a vasoactive octapeptide, has been implicated in cardiac growth and the development of hypertrophy and fibrosis secondary in hypertensive disease. |
1994-02-28 |
2023-08-12 |
Not clear |
| R Natarajan, N Gonzales, L Lanting, J Nadle. Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 23. issue 1 Suppl. 1994-02-16. PMID:8282345. |
however, the relation between lipoxygenase activation and ang ii-induced vascular smooth muscle cell hypertrophy is not known. |
1994-02-16 |
2023-08-12 |
Not clear |
| R Natarajan, N Gonzales, L Lanting, J Nadle. Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 23. issue 1 Suppl. 1994-02-16. PMID:8282345. |
these results suggest that 12-lipoxygenase activation plays a key role in ang ii-induced vascular smooth muscle cell hypertrophy. |
1994-02-16 |
2023-08-12 |
Not clear |
| F J Villarreal, N N Kim, G D Ungab, M P Printz, W H Dillman. Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation. vol 88. issue 6. 1994-01-13. PMID:8252698. |
recent evidence indicates that angiotensin ii (ang ii) might have an important role in the development of myocardial fibrosis accompanying cardiac hypertrophy. |
1994-01-13 |
2023-08-12 |
rat |
| J Sadoshima, Y Xu, H S Slayter, S Izum. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. vol 75. issue 5. 1994-01-10. PMID:8252633. |
using an in vitro model of load (stretch)-induced cardiac hypertrophy, we demonstrate that mechanical stretch causes release of angiotensin ii (ang ii) from cardiac myocytes and that ang ii acts as an initial mediator of the stretch-induced hypertrophic response. |
1994-01-10 |
2023-08-12 |
Not clear |
| C J Oddie, R J Dilley, P Kanellakis, A Bobi. Chronic angiotensin II type 1 receptor antagonism in genetic hypertension: effects on vascular structure and reactivity. Journal of hypertension. vol 11. issue 7. 1993-12-07. PMID:8228190. |
the aim of the study was to assess the role of angiotensin ii (ang ii) in the maintenance of cardiovascular hypertrophy and the abnormal vascular amplifier properties in spontaneously hypertensive rats (shr) with established hypertension. |
1993-12-07 |
2023-08-12 |
rat |