| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Zhen Ma, Lei-Lei Chen, Le Qu, Hui Li, Jun Wang, Ning Song, Jun-Xia Xi. Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice. Acta pharmacologica Sinica. 2023-09-06. PMID:37674043. |
in this study, we explored whether and how environmental insults caused early neuropathological events in the substantia nigra (sn) of a pd mouse model. |
2023-09-06 |
2023-10-07 |
mouse |
| Dong Yeol Kim, Jin Young Shin, Ji Eun Lee, Ha Na Kim, Seok Jong Chung, Han Soo Yoo, Sang Jin Kim, Hwa Jin Cho, Eun-Jae Lee, Soo Jeong Nam, Seong Heon Kim, Jaewon Jang, Seung Eun Lee, Phil Hyu Le. A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669380. |
overexpression of α-synuclein in the er of the substantia nigra (sn) resulted in marked loss of dopaminergic neurons and motor deficits, mimicking pd characteristics. |
2023-09-05 |
2023-10-07 |
Not clear |
| Chen Chu Ying, Cai Shan Wang, Ya Kun Ren, Chang Wei Ding, Ying Chun Zhang, Jian Wu, Min Yang, Ying Zhang, Pan Mao, Yu Jing Sheng, Xiao Fang Chen, Cheng Jie Mao, Chun Feng Li. Correlation Between Substantia Nigra Hyperechogenicity and Iron Metabolism in the Postural Instability Gait Difficulty Subtype of Parkinson's Disease. Ultrasound in medicine & biology. 2023-09-04. PMID:37666708. |
the correlation between substantia nigra (sn) hyperechogenicity on transcranial sonography (tcs) and serum iron metabolism parameters in patients with the postural instability gait difficulty (pigd) subtype of parkinson's disease (pd) was investigated so as to explore the pathological mechanism of sn hyperechogenicity. |
2023-09-04 |
2023-09-07 |
Not clear |
| Tingting Xuan, Xue Fang, Ting Xu, Tingting Ma, Junmei Zhang, Zhenhai Wang, Haining L. Neuromelanin-Sensitive Magnetic Resonance Imaging as a Measure for Differential Diagnosis of Essential Tremor and Parkinson's Disease. Neurology India. vol 71. issue 4. 2023-08-28. PMID:37635504. |
we sought to evaluate whether the neuromelanin-sensitive magnetic resonance imaging (nm-mri) features of the substantia nigra (sn) have utility in the differential diagnosis of parkinson's disease (pd) and essential tremor (et). |
2023-08-28 |
2023-09-07 |
human |
| Saud A Alnaaim, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of Brain Liver X Receptor in Parkinson's Disease: Hidden Treasure and Emerging Opportunities. Molecular neurobiology. 2023-08-22. PMID:37606719. |
parkinson's disease (pd) is a neurodegenerative disease due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-08-22 |
2023-09-07 |
Not clear |
| Mengdi Wang, Fengjiao Sun, Xiaofeng Han, Nan Wang, Yalan Liu, Jinfeng Cai, Shanshan Tong, Rui Wang, Hongcai Wan. Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response. Molecular neurobiology. 2023-08-21. PMID:37603153. |
the increased α-synuclein (α-syn)-dependent activation of cd4 t cells leads to the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2023-08-21 |
2023-09-07 |
rat |
| Margaret P Schmill, Zoe Thompson, Daisy Lee, Laurence Haddadin, Shaarang Mitra, Raymond Ezzat, Samantha Shelton, Phillip Levin, Sogol Behnam, Kelly J Huffman, Theodore Garlan. Hippocampal, whole midbrain, red nucleus, and ventral tegmental area volumes are increased by selective breeding for high voluntary wheel-running behavior. Brain, behavior and evolution. 2023-08-21. PMID:37604130. |
neither linetype nor wheel access affected volumes of the substantia nigra (sn), ventral tegmental area (vta), nucleus accumbens (nac), ventral pallidum (vp) or basolateral amygdala (bla). |
2023-08-21 |
2023-09-07 |
mouse |
| Mingxing Chen, Yutong Wang, Chunyan Zhang, Jun Li, Zhenghao Li, Xiaojun Guan, Jianfeng Bao, Yuyao Zhang, Jingliang Cheng, Hongjiang We. Free water and iron content in the substantia nigra at different stages of Parkinson's disease. European journal of radiology. vol 167. 2023-08-14. PMID:37579561. |
abnormalities in free water (fw) and susceptibility values exist in the substantia nigra (sn) of patients with parkinson's disease (pd), but their role in characterizing the disease processes remains uncertain. |
2023-08-14 |
2023-09-07 |
Not clear |
| Qiang Liu, Pan Wang, Chenghe Liu, Feng Xue, Qian Wang, Yuqing Chen, Ruihua Hou, Teng Che. An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson's disease using neuromelanin-sensitive MRI. BMC neurology. vol 23. issue 1. 2023-08-14. PMID:37580712. |
this case-control study was to investigate the distribution of neuromelanin in the substantia nigra(sn) and the locus coeruleus(lc) using nm-mri technique and evaluate its potential as a diagnostic marker for pd. |
2023-08-14 |
2023-09-07 |
human |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hend Mostafa Selim, Athanasios Alexiou, Marios Papadakis, Walaa A Negm, Gaber El-Saber Batih. Does vitamin D protect or treat Parkinson's disease? A narrative review. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555855. |
parkinson's disease (pd) is a neurodegenerative brain disease (nbd) developed due to dopaminergic neuron loss in the substantia nigra (sn). |
2023-08-09 |
2023-08-16 |
human |
| Amée F Wolters, Margot Heijmans, Nikos Priovoulos, Heidi I L Jacobs, Alida A Postma, Yasin Temel, Mark L Kuijf, Stijn Michiels. Neuromelanin related ultra-high field signal intensity of the locus coeruleus differs between Parkinson's disease and controls. NeuroImage. Clinical. vol 39. 2023-07-26. PMID:37494758. |
until now, most studies have investigated the substantia nigra (sn), while signal changes might be more prominent in the locus coeruleus (lc). |
2023-07-26 |
2023-08-14 |
Not clear |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
the higher expression of clec7a was observed in the substantia nigra (sn) and striatum of pd rats with dopaminergic neurons damage and was mainly localized in the microglial. |
2023-07-26 |
2023-08-14 |
rat |
| Alexandra A Naumova, Ekaterina A Oleynik, Anna V Khramtsova, Svetlana D Nikolaeva, Elena V Chernigovskaya, Margarita V Glazov. Short-term hindlimb unloading negatively affects dopaminergic transmission in the nigrostriatal system of mice. Developmental neurobiology. 2023-07-25. PMID:37489016. |
the nigrostriatal system composed of the dorsal striatum and the substantia nigra (sn) is highly involved in the control of motor behavior. |
2023-07-25 |
2023-08-14 |
mouse |
| Heyue Lu, Bo Zhang, Tingting Yin, Ye Hua, Chenyang Cao, Min Ge, Dandan Shen, You Lang Zhou, Zhongzheng Ji. Ferroptosis-Related Immune Genes in Hematological Diagnosis of Parkinson's Diseases. Molecular neurobiology. 2023-07-15. PMID:37452932. |
we used least absolute shrinkage and selection operator (lasso) to identify the optimal signature ferroptosis-related immune genes based on six gene expression profile datasets of substantia nigra (sn) and peripheral blood of pd patients. |
2023-07-15 |
2023-08-14 |
Not clear |
| Jiri Nepozitek, Zsoka Varga, Simona Dostalova, Pavla Perinova, Jiri Keller, Simon Robinson, Veronika Ibarburu, Iva Prihodova, Ondrej Bezdicek, Evzen Ruzicka, Karel Sonka, Petr Duse. Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder. NPJ Parkinson's disease. vol 9. issue 1. 2023-07-14. PMID:37452075. |
compared to controls, the irbd group had higher ms in bilateral substantia nigra (sn), red nucleus and the ventral tegmental area. |
2023-07-14 |
2023-08-14 |
Not clear |
| Cheng Zhou, Linbo Wang, Wei Cheng, JinChao Lv, Xiaoujun Guan, Tao Guo, Jingjing Wu, Wei Zhang, Ting Gao, Xiaocao Liu, Xueqin Bai, Haoting Wu, Zhengye Cao, Luyan Gu, Jingwen Chen, Jiaqi Wen, Peiyu Huang, Xiaojun Xu, Baorong Zhang, Jianfeng Feng, Minming Zhan. Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-07-13. PMID:37443179. |
the integrity of substantia nigra (sn), locus coeruleus (lc), amygdala, hippocampus, entorhinal cortex, and basal forebrain were assessed using diffusion and neuromelanin-sensitive mri. |
2023-07-13 |
2023-08-14 |
Not clear |
| Zexuan Hu, Peng Sun, Ajit George, Xiangling Zeng, Mengyan Li, Tsen-Hsuan Lin, Zezhong Ye, Xinhua Wei, Xinqing Jiang, Sheng-Kwei Song, Ruimeng Yan. Diffusion basis spectrum imaging detects pathological alterations in substantia nigra and white matter tracts with early-stage Parkinson's disease. European radiology. 2023-07-12. PMID:37438642. |
using diffusion basis spectrum imaging (dbsi) to examine the microstructural changes in the substantia nigra (sn) and global white matter (wm) tracts of patients with early-stage pd. |
2023-07-12 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Abdul-Karim Abd Ali Al-Mahammadawy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. The potential role of cholesterol in Parkinson's disease neuropathology: perpetrator or victim. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-07-10. PMID:37428278. |
additionally, cholesterol increases aggregation of α-synuclein and induces degeneration of dopaminergic neurons (dn) in the substantia nigra (sn). |
2023-07-10 |
2023-08-14 |
Not clear |
| Carmela Conte, Angela Ingrassia, John Breve, John J Bol, Evelien Timmermans-Huisman, Anne-Marie van Dam, Tommaso Beccari, Wilma D J van de Ber. Toll-like Receptor 4 Is Upregulated in Parkinson's Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology. Cells. vol 12. issue 10. 2023-07-06. PMID:37408202. |
in this study, we analyzed the expression of tlr4 in the substantia nigra (sn) and medial temporal gyrus (gtm) of well-characterized pd patients and age-matched controls. |
2023-07-06 |
2023-08-14 |
Not clear |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death in the substantia nigra (sn). |
2023-06-29 |
2023-08-14 |
rat |