| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyin Wu, Brian O'Neill, Dawn D Han, Keerthi Thirtamara-Rajamani, Yanlin Wang, Howard H G. Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology. vol 86. 2015-07-14. PMID:24835281. |
in the current study, we expanded the aav-datwt infected areas to cover the olfactory tubercle (tu) and the ventral midbrain (vmb) containing the ventral tegmental area (vta) and substantia nigra (sn) in addition to cpu and nac with multiple injections. |
2015-07-14 |
2023-08-13 |
mouse |
| Sachin P Patil, Pankaj D Jain, Jayant S Sancheti, Priya J Ghumatkar, Rufi Tambe, Sadhana Sathay. Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice. Neuropharmacology. vol 86. 2015-07-14. PMID:25087727. |
tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap) and brain derived neurotrophic factor (bdnf) were evaluated in substantia nigra (sn) region of the brain by immunostaining. |
2015-07-14 |
2023-08-13 |
mouse |
| Lucía F Cardo, Eliecer Coto, René Ribacoba, Ignacio F Mata, Germán Moris, Manuel Menéndez, Victoria Alvare. The screening of the 3'UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease. Journal of human genetics. vol 59. issue 6. 2015-07-13. PMID:24758914. |
we found a significant lower level of the lrrk2 transcript in the substantia nigra (sn) of pd postmortem donors (n=9) who were rs66737902 c carriers (p=0.01). |
2015-07-13 |
2023-08-13 |
Not clear |
| Mahalakshmi Subramaniam, Daniel Althof, Suzana Gispert, Jochen Schwenk, Georg Auburger, Akos Kulik, Bernd Fakler, Jochen Roepe. Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 41. 2015-07-08. PMID:25297088. |
parkinson disease (pd) is an α-synucleinopathy resulting in the preferential loss of highly vulnerable dopamine (da) substantia nigra (sn) neurons. |
2015-07-08 |
2023-08-13 |
mouse |
| Mahmoud M Iravani, Mona Sadeghian, Sarah Rose, Peter Jenne. Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24781752. |
we examine if destruction of the locus coeruleus with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4) alters dopaminergic cell loss in substantia nigra (sn) initiated by lipopolysaccharide (lps) in the rat through an effect on glial cell activation. |
2015-07-07 |
2023-08-13 |
rat |
| Xiqi Liu, Rushing Shao, Meng Li, Guofeng Yan. Edaravone protects neurons in the rat substantia nigra against 6-hydroxydopamine-induced oxidative stress damage. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24948472. |
to investigate the mechanism of the neuroprotective effect of edaravone in substantia nigra (sn) of the 6-ohda-induced rat model of parkinson's disease. |
2015-07-02 |
2023-08-13 |
rat |
| Hongcai Wang, Yan Chen, Jinbo Chen, Zhentao Zhang, Wansheng Lao, Xizhi Li, Jinsha Huang, Tao Wan. Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. PloS one. vol 9. issue 10. 2015-06-23. PMID:25303312. |
the cell cycle was reactivated in cyclin d-expressing dopaminergic neurons from the substantia nigra (sn) of rats following stereotactic (st) infusion of rotenone. |
2015-06-23 |
2023-08-13 |
rat |
| Stéphane Lehéricy, Eric Bardinet, Cyril Poupon, Marie Vidailhet, Chantal Françoi. 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 13. 2015-06-22. PMID:25308960. |
until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (sn) directly. |
2015-06-22 |
2023-08-13 |
human |
| Gesthimani Samiotaki, Camilo Acosta, Shutao Wang, Elisa E Konofago. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 4. 2015-06-16. PMID:25586140. |
the brain's ascending nigrostriatal pathway is severely damaged in parkinson's disease (pd), and therefore the substantia nigra (sn) and striatal caudoputamen (cp) were selected as the target areas. |
2015-06-16 |
2023-08-13 |
Not clear |
| Sabine Krabbe, Johanna Duda, Julia Schiemann, Christina Poetschke, Gaby Schneider, Eric R Kandel, Birgit Liss, Jochen Roeper, Eleanor H Simpso. Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 12. 2015-06-15. PMID:25675529. |
here, we show that in vivo, both the firing rate (tonic activity) and burst firing (phasic activity) of identified midbrain da neurons are impaired in the ventral tegmental area (vta), but not in the substantia nigra (sn), of d2r-oe mice. |
2015-06-15 |
2023-08-13 |
mouse |
| Diego Iacono, Maria Geraci-Erck, Hui Peng, Marcie L Rabin, Roger Kurla. Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor and other hyperkinetic movements (New York, N.Y.). vol 5. 2015-06-13. PMID:26069855. |
previous neuropathologic studies have reported generically defined neuronal loss in various cerebral regions of dys brains, mostly in the basal ganglia (bg), and specifically in the substantia nigra (sn). |
2015-06-13 |
2023-08-13 |
Not clear |
| L P Voitenko, A G Nikonenk. [Modification of experimental rotenone model of Parkinson's disease]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 61. issue 1. 2015-06-11. PMID:26040040. |
a modification of experimental model of parkinson's disease is proposed presuming the stereotaxic infusion of rotenone solution using a special device into the cental part of substantia nigra (sn) pars compacta of adult wistar rats. |
2015-06-11 |
2023-08-13 |
rat |
| S P Patil, P D Jain, P J Ghumatkar, R Tambe, S Sathay. Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience. vol 277. 2015-06-08. PMID:25108167. |
dopaminergic degeneration was evaluated by analyzing the tyrosine hydroxylase (th) by immunostaining and nissl staining of the substantia nigra (sn) region of the brain. |
2015-06-08 |
2023-08-13 |
mouse |
| Ye Lee Jun, Chang-Hwan Bae, Dongsoo Kim, Sungtae Koo, Seungtae Ki. Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model. Journal of ginseng research. vol 39. issue 2. 2015-06-05. PMID:26045688. |
the present study investigated a possible role of korean red ginseng (krg) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (sn) and striatum (st) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinson's disease mouse model. |
2015-06-05 |
2023-08-13 |
mouse |
| Annamaria Lanzillotta, Vanessa Porrini, Arianna Bellucci, Marina Benarese, Caterina Branca, Edoardo Parrella, Pier Franco Spano, Marina Pizz. NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases. Frontiers in neurology. vol 6. 2015-06-04. PMID:26042083. |
constitutive knockout of c-rel shatters the resilience of substantia nigra (sn) dopaminergic (da) neurons to aging and induces a parkinsonian like pathology in mice. |
2015-06-04 |
2023-08-13 |
mouse |
| Vladimir Miletić, David Ozretić, Maja Relj. Parkinsonian syndrome and ataxia as a presenting finding of acquired hepatocerebral degeneration. Metabolic brain disease. vol 29. issue 1. 2015-06-02. PMID:24390157. |
predilection brain regions for manganese deposits are globus pallidum (gp) and substantia nigra (sn). |
2015-06-02 |
2023-08-12 |
Not clear |
| Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that results mainly due to the death of dopaminergic neurons in the substantia nigra (sn), and subsequently has an effect on one's motor function and coordination. |
2015-06-02 |
2023-08-12 |
mouse |
| Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma Dj van de Berg, Paul J Lucassen, Anne-Marie van Da. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25099483. |
next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2015-05-29 |
2023-08-13 |
Not clear |
| Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair R R Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer, Claudia Lodovichi, Charles Plessy, Piero Carninci, Stefano Gustincic. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC genomics. vol 15. 2015-05-28. PMID:25164183. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2015-05-28 |
2023-08-13 |
Not clear |
| Stefanie L O'Neal, Jang-Won Lee, Wei Zheng, Jason R Canno. Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity. Neurotoxicology. vol 44. 2015-05-27. PMID:25117542. |
the current study used high performance liquid chromatography to quantify neurotransmitter levels in rat striatum (str), substantia nigra (sn), and hippocampus (hp). |
2015-05-27 |
2023-08-13 |
rat |