| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Kang Tao, Qin Tang, Jin-Jin Dai, Yuan-Yuan Li, Ming-Yan He. [Impact of dopamine receptor modulation on reduced anxiety-like behavior in neonatal rats after hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 16. issue 10. 2015-04-17. PMID:25344189. |
to observe the long-term changes in anxiety-like behavior and tyrosine hydroxylase (th) expression in the substantia nigra (sn) after hypoxic-ischemic brain damage (hibd) in a neonatal rat model and to further explore the relationship between dopamine (da) level and long-term anxiety-like behavior using the da receptor (dar) antagonist. |
2015-04-17 |
2023-08-13 |
rat |
| Jie Li, Terence Duarte, Arif Kocabas, Melissa Works, Susan K McConnell, Mary A Hyne. Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24867253. |
there are two main subgroups of midbrain dopaminergic (da) neurons: the more medially located ventral tegmental area (vta) da neurons, which have axons that innervate the ventral-lateral (vl) striatum, and the more laterally located substantia nigra (sn) da neurons, which preferentially degenerate in parkinson's disease (pd) and have axons that project to the dorsal-medial (dm) striatum. |
2015-04-15 |
2023-08-13 |
mouse |
| Hideto Miw. [Transcranial sonography of substantia nigra in patients with Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291852. |
substantia nigra (sn) hyperechogenicity, as visualized by transcranial sonography, has been heralded as a particularly useful diagnostic marker, as it is stable and remains unchanged with advancing stages of pd. |
2015-04-13 |
2023-08-12 |
Not clear |
| Sandra A Acosta, Naoki Tajiri, Ike de la Pena, Marina Bastawrous, Paul R Sanberg, Yuji Kaneko, Cesar V Borlonga. Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease. Journal of cellular physiology. vol 230. issue 5. 2015-04-10. PMID:25251017. |
however, preclinical studies on the pathophysiological changes in substantia nigra (sn) after chronic tbi are lacking. |
2015-04-10 |
2023-08-13 |
rat |
| Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstei. Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease. Molecular neurodegeneration. vol 9. 2015-03-30. PMID:25011704. |
the substantia nigra (sn) midbrain nucleus is constitutively iron rich. |
2015-03-30 |
2023-08-13 |
mouse |
| Marta Esteves, Ana C Cristóvão, Tatiana Saraiva, Sandra M Rocha, Graça Baltazar, Lino Ferreira, Liliana Bernardin. Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease. Frontiers in aging neuroscience. vol 7. 2015-03-23. PMID:25798108. |
the results showed that the ra-nps administration induced a significant reduction of da neuron loss in the substantia nigra (sn) as well as their neuronal fiber/axonal innervations in the striatum. |
2015-03-23 |
2023-08-13 |
mouse |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (vta) and the other in the substantia nigra (sn). |
2015-03-20 |
2023-08-13 |
Not clear |
| Shu-ju Wang, Jun Ma, Yuan-xun Gong, Yan-chun Wang, Xiao-ling Zeng, Yan Liang, Guo-jie Su. [Effect of electroacupuncture intervention on ERK 1/2 signaling and TNF-α and IL-1β protein levels in the substantia Nigra in rats with Parkinson's Disease]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 6. 2015-03-20. PMID:25632569. |
to observe the effect of electroacupuncture(ea) on phosphalized extracellular regulated protein kinases(p-erk) 1/2 signaling pathway and tumor necrosis factor (tnf)-α and il-1β protein levels in the substantia nigra (sn) in rats with parkinson's disease (pd), so as to explore its mechanism underlying improvement of pd. |
2015-03-20 |
2023-08-13 |
rat |
| Timothy M Ellmore, Sara M Murphy, Katarina Cruz, Richard J Castriotta, Mya C Schies. Averaging of diffusion tensor imaging direction-encoded color maps for localizing substantia nigra. Computers in biology and medicine. vol 51. 2015-03-12. PMID:24905890. |
here we present a simple method for averaging direction-encoded color anisotropy maps in standard space, explore this technique for visualizing the substantia nigra (sn) in relation to other midbrain structures, and show with signal-to-noise analysis that averaging improves the direction-encoded color signature. |
2015-03-12 |
2023-08-13 |
human |
| Yiming Xiao, Pierre Jannin, Tiziano D'Albis, Nicolas Guizard, Claire Haegelen, Florent Lalys, Marc Vérin, D Louis Collin. Investigation of morphometric variability of subthalamic nucleus, red nucleus, and substantia nigra in advanced Parkinson's disease patients using automatic segmentation and PCA-based analysis. Human brain mapping. vol 35. issue 9. 2015-03-06. PMID:24652699. |
conventional methods employ standard atlas coordinates to target the stn, which, along with the adjacent red nucleus (rn) and substantia nigra (sn), are not well visualized on conventional t1w mris. |
2015-03-06 |
2023-08-12 |
Not clear |
| Youngsin Jung, Dennis W Dickson, Melissa E Murray, Jennifer L Whitwell, David S Knopman, Bradley F Boeve, Clifford R Jack, Joseph E Parisi, Ronald C Petersen, Keith A Joseph. TDP-43 in Alzheimer's disease is not associated with clinical FTLD or Parkinsonism. Journal of neurology. vol 261. issue 7. 2015-03-02. PMID:24760339. |
some of these ad cases have tdp-43 immunoreactivity in basal ganglia (bg) and substantia nigra (sn), regions that when affected can be associated with parkinsonian signs or symptoms, or even features suggestive of frontotemporal dementia. |
2015-03-02 |
2023-08-13 |
Not clear |
| Li Zhou, Zhi-Yong Wang, Hui Lian, Hai-Yan Song, Yi-Min Zhang, Xiao-Li Zhang, Rui-Fang Fan, Li-Fei Zheng, Jin-Xia Zh. Altered expression of dopamine receptors in cholinergic motoneurons of the hypoglossal nucleus in a 6-OHDA-induced Parkinson's disease rat model. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25172664. |
however, the link between the degenerated dopaminergic neurons in the substantia nigra (sn) and lingual dysfunction remains unclear. |
2015-02-25 |
2023-08-13 |
rat |
| Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, Xiao-Ping P. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PloS one. vol 8. issue 10. 2015-02-23. PMID:24205164. |
meanwhile, in an mptp mouse model, pal prevented a decrease of the contents of dopamine (da) and its metabolites in the striatum and th-positive dopaminergic neuron loss in the substantia nigra (sn). |
2015-02-23 |
2023-08-12 |
mouse |
| A Ninh Pham, T David Wait. Cu(II)-catalyzed oxidation of dopamine in aqueous solutions: mechanism and kinetics. Journal of inorganic biochemistry. vol 137. 2015-02-12. PMID:24815905. |
spontaneous oxidation of dopamine (da) and the resultant formation of free radical species within dopamine neurons of the substantia nigra (sn) is thought to bestow a considerable oxidative load upon these neurons and may contribute to their vulnerability to degeneration in parkinson's disease (pd). |
2015-02-12 |
2023-08-13 |
Not clear |
| M J Barallobre, C Perier, J Bové, A Laguna, J M Delabar, M Vila, M L Arboné. DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. Cell death & disease. vol 5. 2015-02-12. PMID:24922073. |
the mouse model for dyrk1a haploinsufficiency (the dyrk1a(+/-) mouse) presents neuronal deficits in specific regions of the adult brain, including the substantia nigra (sn), although the mechanisms underlying these pathogenic effects remain unclear. |
2015-02-12 |
2023-08-13 |
mouse |
| Chen Qi, Mingxin Xu, Jing Gan, Xinxin Yang, Na Wu, Lu Song, Weien Yuan, Zhenguo Li. Erythropoietin improves neurobehavior by reducing dopaminergic neuron loss in a 6‑hydroxydopamine‑induced rat model. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24939444. |
the number of tyrosine hydroxylase (th)‑immunopositive cells in the substantia nigra (sn) was measured by immuno-cyto-chemistry. |
2015-02-12 |
2023-08-13 |
rat |
| Omri Lamm, Javier Ganz, Eldad Melamed, Daniel Offe. Harnessing neurogenesis for the possible treatment of Parkinson's disease. The Journal of comparative neurology. vol 522. issue 12. 2015-02-09. PMID:24723264. |
neural precursor cells, which have been found in various parts of the brain, e.g., the subventricular zone (svz) and substantia nigra (sn), have promising potential to replace the extensive loss of neurons occurring in neurodegenerative disorders. |
2015-02-09 |
2023-08-13 |
Not clear |
| Falk Schlaudraff, Jan Gründemann, Michael Fauler, Elena Dragicevic, John Hardy, Birgit Lis. Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24742361. |
progressive loss of substantia nigra dopamine neurons (sn da) is a hallmark of aging and of parkinson's disease (pd). |
2015-02-09 |
2023-08-13 |
human |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song L. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental neurology. vol 263. 2015-02-09. PMID:25263579. |
application of a potent activator of aldh2, alda-1, was effective in protecting against rotenone-induced apoptotic cell death in both sh-sy5y cells and primary cultured substantia nigra (sn) dopaminergic neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Anne Grünewald, Nichola Z Lax, Mariana C Rocha, Amy K Reeve, Philippa D Hepplewhite, Karolina A Rygiel, Robert W Taylor, Doug M Turnbul. Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. Journal of neuroscience methods. vol 232. 2015-02-07. PMID:24880043. |
in substantia nigra (sn) neurons from parkinson's disease patients. |
2015-02-07 |
2023-08-13 |
human |