| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Abate, K Hernández-Fonseca, A C Reyes-Guzmán, I G Barbosa-Luna, M Ménde. Prenatal ethanol exposure alters met-enkephalin expression in brain regions related with reinforcement: possible mechanism for ethanol consumption in offspring. Behavioural brain research. vol 274. 2015-05-26. PMID:25150040. |
met-enk content was assessed in the ventral tegmental area [vta], nucleus accumbens [nacc], prefrontal cortex [pfc], substantia nigra [sn], caudate-putamen [cp], amygdala, hypothalamus and hippocampus. |
2015-05-26 |
2023-08-13 |
rat |
| Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
however, nimodipine and nifedipine significantly enhanced the survival of dopaminergic substantia nigra (sn) but not ventral tegmental area (vta) neurons, while nicardipine, isradipine and verapamil had no effect. |
2015-05-21 |
2023-08-13 |
rat |
| Hashem Haghdoost-Yazdi, Mohammad Sarookhani, Ayda Faraj, Negin Fraidouni, Tahereh Dargahi, Mohammad Hosein Yaghoubidoust, Hassan Azhdari-Zarmehr. Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24992727. |
considering the direct correlation between the severity of rotational behavior and the degree of lesion in the substantia nigra (sn), our data indicate that higher thcy values can predict higher sn dopaminergic neurodegeneration. |
2015-05-19 |
2023-08-13 |
rat |
| Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Li. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genetics and molecular biology. vol 38. issue 1. 2015-05-18. PMID:25983633. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (sn). |
2015-05-18 |
2023-08-13 |
mouse |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
until now there is lack of animal experimental data on the supportive effect of estrogen on function of dopaminergic neurons in substantia nigra (sn) in physiological state. |
2015-05-16 |
2023-08-12 |
human |
| Vishnu P Murty, Maheen Shermohammed, David V Smith, R McKell Carter, Scott A Huettel, R Alison Adcoc. Resting state networks distinguish human ventral tegmental area from substantia nigra. NeuroImage. vol 100. 2015-05-12. PMID:24979343. |
one schema originating in rodent models delineated ventral tegmental area (vta), implicated in complex behaviors like addiction, from more lateral substantia nigra (sn), preferentially implicated in movement. |
2015-05-12 |
2023-08-13 |
human |
| Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasie. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24969022. |
these results demonstrate that inactivation of the pink1 or dj-1 genes in the rat produces progressive neurodegeneration and early behavioral deficits, suggesting that these recessive genes may be essential for the survival of dopaminergic neurons in the substantia nigra (sn). |
2015-04-21 |
2023-08-13 |
rat |
| Hui-Kang Tao, Qin Tang, Jin-Jin Dai, Yuan-Yuan Li, Ming-Yan He. [Impact of dopamine receptor modulation on reduced anxiety-like behavior in neonatal rats after hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 16. issue 10. 2015-04-17. PMID:25344189. |
to observe the long-term changes in anxiety-like behavior and tyrosine hydroxylase (th) expression in the substantia nigra (sn) after hypoxic-ischemic brain damage (hibd) in a neonatal rat model and to further explore the relationship between dopamine (da) level and long-term anxiety-like behavior using the da receptor (dar) antagonist. |
2015-04-17 |
2023-08-13 |
rat |
| Jie Li, Terence Duarte, Arif Kocabas, Melissa Works, Susan K McConnell, Mary A Hyne. Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24867253. |
there are two main subgroups of midbrain dopaminergic (da) neurons: the more medially located ventral tegmental area (vta) da neurons, which have axons that innervate the ventral-lateral (vl) striatum, and the more laterally located substantia nigra (sn) da neurons, which preferentially degenerate in parkinson's disease (pd) and have axons that project to the dorsal-medial (dm) striatum. |
2015-04-15 |
2023-08-13 |
mouse |
| Hideto Miw. [Transcranial sonography of substantia nigra in patients with Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291852. |
substantia nigra (sn) hyperechogenicity, as visualized by transcranial sonography, has been heralded as a particularly useful diagnostic marker, as it is stable and remains unchanged with advancing stages of pd. |
2015-04-13 |
2023-08-12 |
Not clear |
| Sandra A Acosta, Naoki Tajiri, Ike de la Pena, Marina Bastawrous, Paul R Sanberg, Yuji Kaneko, Cesar V Borlonga. Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease. Journal of cellular physiology. vol 230. issue 5. 2015-04-10. PMID:25251017. |
however, preclinical studies on the pathophysiological changes in substantia nigra (sn) after chronic tbi are lacking. |
2015-04-10 |
2023-08-13 |
rat |
| Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstei. Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease. Molecular neurodegeneration. vol 9. 2015-03-30. PMID:25011704. |
the substantia nigra (sn) midbrain nucleus is constitutively iron rich. |
2015-03-30 |
2023-08-13 |
mouse |
| Marta Esteves, Ana C Cristóvão, Tatiana Saraiva, Sandra M Rocha, Graça Baltazar, Lino Ferreira, Liliana Bernardin. Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease. Frontiers in aging neuroscience. vol 7. 2015-03-23. PMID:25798108. |
the results showed that the ra-nps administration induced a significant reduction of da neuron loss in the substantia nigra (sn) as well as their neuronal fiber/axonal innervations in the striatum. |
2015-03-23 |
2023-08-13 |
mouse |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (vta) and the other in the substantia nigra (sn). |
2015-03-20 |
2023-08-13 |
Not clear |
| Shu-ju Wang, Jun Ma, Yuan-xun Gong, Yan-chun Wang, Xiao-ling Zeng, Yan Liang, Guo-jie Su. [Effect of electroacupuncture intervention on ERK 1/2 signaling and TNF-α and IL-1β protein levels in the substantia Nigra in rats with Parkinson's Disease]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 6. 2015-03-20. PMID:25632569. |
to observe the effect of electroacupuncture(ea) on phosphalized extracellular regulated protein kinases(p-erk) 1/2 signaling pathway and tumor necrosis factor (tnf)-α and il-1β protein levels in the substantia nigra (sn) in rats with parkinson's disease (pd), so as to explore its mechanism underlying improvement of pd. |
2015-03-20 |
2023-08-13 |
rat |
| Timothy M Ellmore, Sara M Murphy, Katarina Cruz, Richard J Castriotta, Mya C Schies. Averaging of diffusion tensor imaging direction-encoded color maps for localizing substantia nigra. Computers in biology and medicine. vol 51. 2015-03-12. PMID:24905890. |
here we present a simple method for averaging direction-encoded color anisotropy maps in standard space, explore this technique for visualizing the substantia nigra (sn) in relation to other midbrain structures, and show with signal-to-noise analysis that averaging improves the direction-encoded color signature. |
2015-03-12 |
2023-08-13 |
human |
| Yiming Xiao, Pierre Jannin, Tiziano D'Albis, Nicolas Guizard, Claire Haegelen, Florent Lalys, Marc Vérin, D Louis Collin. Investigation of morphometric variability of subthalamic nucleus, red nucleus, and substantia nigra in advanced Parkinson's disease patients using automatic segmentation and PCA-based analysis. Human brain mapping. vol 35. issue 9. 2015-03-06. PMID:24652699. |
conventional methods employ standard atlas coordinates to target the stn, which, along with the adjacent red nucleus (rn) and substantia nigra (sn), are not well visualized on conventional t1w mris. |
2015-03-06 |
2023-08-12 |
Not clear |
| Youngsin Jung, Dennis W Dickson, Melissa E Murray, Jennifer L Whitwell, David S Knopman, Bradley F Boeve, Clifford R Jack, Joseph E Parisi, Ronald C Petersen, Keith A Joseph. TDP-43 in Alzheimer's disease is not associated with clinical FTLD or Parkinsonism. Journal of neurology. vol 261. issue 7. 2015-03-02. PMID:24760339. |
some of these ad cases have tdp-43 immunoreactivity in basal ganglia (bg) and substantia nigra (sn), regions that when affected can be associated with parkinsonian signs or symptoms, or even features suggestive of frontotemporal dementia. |
2015-03-02 |
2023-08-13 |
Not clear |
| Li Zhou, Zhi-Yong Wang, Hui Lian, Hai-Yan Song, Yi-Min Zhang, Xiao-Li Zhang, Rui-Fang Fan, Li-Fei Zheng, Jin-Xia Zh. Altered expression of dopamine receptors in cholinergic motoneurons of the hypoglossal nucleus in a 6-OHDA-induced Parkinson's disease rat model. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25172664. |
however, the link between the degenerated dopaminergic neurons in the substantia nigra (sn) and lingual dysfunction remains unclear. |
2015-02-25 |
2023-08-13 |
rat |
| Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, Xiao-Ping P. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PloS one. vol 8. issue 10. 2015-02-23. PMID:24205164. |
meanwhile, in an mptp mouse model, pal prevented a decrease of the contents of dopamine (da) and its metabolites in the striatum and th-positive dopaminergic neuron loss in the substantia nigra (sn). |
2015-02-23 |
2023-08-12 |
mouse |