| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongbin Han, Chunyan Shi, Yu Fu, Long Zuo, Kejia Lee, Qingyuan He, Haojun Ha. A novel MRI tracer-based method for measuring water diffusion in the extracellular space of the rat brain. IEEE journal of biomedical and health informatics. vol 18. issue 3. 2015-02-02. PMID:24808229. |
); and 4) substantia nigra (sn.). |
2015-02-02 |
2023-08-13 |
rat |
| Domenico Aquino, Valeria Contarino, Alberto Albanese, Ludovico Minati, Laura Farina, Marina Grisoli, Luigi Romita, Antonio Emanuele Elia, Antonio Elia, Maria Grazia Bruzzone, Luisa Chiapparin. Substantia nigra in Parkinson's disease: a multimodal MRI comparison between early and advanced stages of the disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24337946. |
this study focused on the substantia nigra (sn) in parkinson's disease (pd). |
2015-01-27 |
2023-08-12 |
human |
| Wei Zhang, Zhao-fen Yan, Jun-hua Gao, Li Sun, Xi-yan Huang, Zhuo Liu, Shu-yang Yu, Chen-Jie Cao, Li-jun Zuo, Ze-Jie Chen, Yang Hu, Fang Wang, Jau-shyong Hong, Xiao-min Wan. Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration. Molecular neurobiology. vol 49. issue 3. 2015-01-26. PMID:24277523. |
parkinson's disease (pd) patients have excessive iron depositions in substantia nigra (sn). |
2015-01-26 |
2023-08-12 |
mouse |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
the neuroprotective effect of dbyw and qzs on dopamine (da) neurons in substantia nigra (sn) in the mptp-induced pd mice was investigated by behavioral test (pole test) and immunohistochemistry. |
2015-01-22 |
2023-08-13 |
mouse |
| Shane W Savage, David H Zald, Ronald L Cowan, Nora D Volkow, Pamela A Marks-Shulman, Robert M Kessler, Naji N Abumrad, Julia P Dun. Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity. Obesity (Silver Spring, Md.). vol 22. issue 6. 2015-01-16. PMID:24415718. |
in healthy, ns are negatively associated with da receptors in the substantia nigra (sn). |
2015-01-16 |
2023-08-12 |
Not clear |
| Y Tang, T Li, J Li, J Yang, H Liu, X J Zhang, W L. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease. Cell death and differentiation. vol 21. issue 3. 2015-01-15. PMID:24212761. |
we also observed that the suppression of jmjd3 in the substantia nigra (sn) in vivo dramatically caused microglial overactivation and exacerbated dopamine (da) neuron death in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-intoxicated mouse model of pd. |
2015-01-15 |
2023-08-12 |
mouse |
| Shinji Oikawa, Hatasu Kobayashi, Yuki Kitamura, Hong Zhu, Kumi Obata, Yoshio Minabe, Maryia Dazortsava, Kyoko Ohashi, Saeko Tada-Oikawa, Hitoshi Takahashi, Kenichiro Yata, Mariko Murata, Tetsumori Yamashim. Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion. Free radical research. vol 48. issue 6. 2015-01-10. PMID:24697733. |
in parkinson's disease (pd), oxidative stresses cause cell death of dopaminergic neurons of the substantia nigra (sn), but its molecular mechanism still remains unclarified. |
2015-01-10 |
2023-08-13 |
monkey |
| L-F Zheng, J Song, R-F Fan, C-L Chen, Q-Z Ren, X-L Zhang, X-Y Feng, Y Zhang, L-S Li, J-X Zh. The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta physiologica (Oxford, England). vol 211. issue 2. 2015-01-09. PMID:24410908. |
we previously reported on the impaired gastric motility in 6-hydroxydopamine (6-ohda) rats, which were treated with a bilateral microinjection of 6-ohda in the substantia nigra (sn). |
2015-01-09 |
2023-08-12 |
rat |
| Sinem Aras, Gamze Tanriover, Mutay Aslan, Piraye Yargicoglu, Aysel Aga. The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice. Neurochemistry international. vol 72. 2015-01-09. PMID:24795109. |
dopaminergic neuron death at substantia nigra (sn) was determined by immunohistochemical analysis of tyrosine hydroxylase (th). |
2015-01-09 |
2023-08-13 |
mouse |
| Kazumasa Wakamatsu, Hitomi Tanaka, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin. Molecules (Basel, Switzerland). vol 19. issue 6. 2015-01-09. PMID:24936706. |
neuromelanin (nm) is produced in dopaminergic neurons of the substantia nigra (sn) and in noradrenergic neurons of the locus coeruleus (lc). |
2015-01-09 |
2023-08-13 |
Not clear |
| Edson Bor-Seng-Shu, Jose Luiz Pedroso, Andre C Felicio, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Pedro Braga-Neto, Ilza Rosa Batista, Orlando Graziani Povoas Barsottini, Vanderci Borges, Henrique Ballalai Ferraz, Ming Chi Shih, Rodrigo A Bressan, Luiz Augusto Franco de Andrade, Uwe Walte. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: a cross-sectional study. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24629800. |
the current study addresses the use of transcranial sonography and single-photon emission computed tomography (spect) using (99m)tc-trodat-1 to evaluate the echogenicity of the substantia nigra (sn) and the density of striatal presynaptic dopamine transporters, respectively, in a sample of 20 pd patients (13 males and 7 females) and 9 healthy subjects. |
2015-01-07 |
2023-08-12 |
human |
| Da-Wei Li, Zhi-Qiang Liu, Wei Chen, Min Yao, Guang-Ren L. Association of glycogen synthase kinase-3β with Parkinson's disease (review). Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24681994. |
the present review focuses on the involvement of this protein in parkinson's disease (pd), a common neurodegenerative disorder characterized by the gradually progressive and selective loss of dopaminergic neurons, and by intracellular inclusions known as lewy bodies (lbs) expressed in surviving neurons of the substantia nigra (sn). |
2015-01-05 |
2023-08-12 |
Not clear |
| Mary V Burke, Christine Nocjar, Alex J Sonneborn, Andrew C McCreary, Elizabeth A Pehe. Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra. Journal of neurochemistry. vol 131. issue 4. 2015-01-05. PMID:25073477. |
this study used dual-probe in vivo microdialysis to investigate the relative contributions of 5-ht2c receptors localized in the rat substantia nigra (sn) and caudate-putamen (cp) in the control of nigrostriatal da release. |
2015-01-05 |
2023-08-13 |
rat |
| Kai-Chih Hung, Hui-Ju Huang, Ming-Wei Lin, Yen-Ping Lei, Anya Maan-yuh Li. Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation. PloS one. vol 9. issue 3. 2014-12-23. PMID:24646838. |
the oxidative mechanism underlying mpp+-induced neurotoxicity was identified by elevated lipid peroxidation and heme oxygenase-1 levels, a redox-regulated protein in mpp+-infused substantia nigra (sn). |
2014-12-23 |
2023-08-12 |
rat |
| Elena A Kozina, Gulnara R Khakimova, Vitaly G Khaindrava, Valeriayn G Kucheryanu, Nadezhda E Vorobyeva, Alexey N Krasnov, Sophia G Georgieva, Lidiya Kerkerian-Le Goff, Michael V Ugrumo. Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24768159. |
according to our data, a partial degeneration of da-ergic neurons at the presymptomatic stage was accompanied by: (i) no change in th mrna content in the substantia nigra (sn) suggesting a compensatory increase of th gene expression in individual neurons; (ii) a decrease of th protein content in the nigrostriatal system and no change in individual neurons, suggesting a slowdown of th translation. |
2014-12-22 |
2023-08-13 |
mouse |
| Michael Hutchinson, Ulrich Raff, Pedro Chaná, Isidro Huet. Spin-lattice distribution MRI maps nigral pathology in progressive supranuclear palsy (PSP) during life: a pilot study. PloS one. vol 9. issue 1. 2014-12-18. PMID:24489655. |
the exception is spin-lattice distribution mri (sld-mri), a technique which detects changes in the substantia nigra (sn) due to changes in the spin-lattice relaxation time, t1. |
2014-12-18 |
2023-08-12 |
human |
| Sara E Gombash, Fredric P Manfredsson, Christopher J Kemp, Nathan C Kuhn, Sheila M Fleming, Ann E Egan, Laura M Grant, Michelle R Ciucci, Jeffrey P MacKeigan, Caryl E Sortwel. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. PloS one. vol 8. issue 11. 2014-12-17. PMID:24312298. |
the goal of these series of experiments was to characterize the neurodegeneration and functional deficits resulting from injection of recombinant adeno-associated virus (raav) serotype 2/5-expressing human wildtype α-syn in the rat substantia nigra (sn). |
2014-12-17 |
2023-08-12 |
human |
| Romina Mizrahi, Miran Kenk, Ivonne Suridjan, Isabelle Boileau, Tony P George, Kwame McKenzie, Alan A Wilson, Sylvain Houle, Pablo Rusja. Stress-induced dopamine response in subjects at clinical high risk for schizophrenia with and without concurrent cannabis use. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24385130. |
the simplified reference tissue model was used to obtain binding potential relative to non-displaceable binding (bpnd) in the whole striatum, its functional subdivisions (limbic striatum (lst), associative striatum (ast), and sensorimotor striatum (smst)), globus pallidus (gp), and substantia nigra (sn). |
2014-12-15 |
2023-08-12 |
human |
| Marta R S Carmo, Ana Paula F Menezes, Ana Carla L Nunes, Anna Pliássova, Anabela P Rolo, Carlos M Palmeira, Rodrigo A Cunha, Paula M Canas, Geanne M Andrad. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology. vol 81. 2014-12-15. PMID:24508709. |
parkinson's disease (pd) involves an initial loss of striatal dopaminergic terminals evolving into a degeneration of dopaminergic neurons in the substantia nigra (sn), which can be modeled by 6-hydroxydopamine (6-ohda) administration. |
2014-12-15 |
2023-08-12 |
rat |
| Un Ju Jung, Min-Tae Jeon, Myung-Sook Choi, Sang Ryong Ki. Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo. Journal of medicinal food. vol 17. issue 5. 2014-12-15. PMID:24660866. |
silibinin treatment with 10 mg/kg had no significantly neuroprotective effects in the substantia nigra (sn). |
2014-12-15 |
2023-08-12 |
Not clear |