| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuangui Zhu, Paul M Carvey, Zaodung Lin. Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide. Neurochemistry international. vol 50. issue 4. 2007-06-14. PMID:17291629. |
additionally, prenatal lps exposure produced a reduction of da neuron count in the substantia nigra (sn). |
2007-06-14 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Kochupurackal P Mohanakuma. Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. Journal of pineal research. vol 42. issue 3. 2007-06-14. PMID:17349022. |
we also studied the effect of melatonin on rotenone-induced changes in the antioxidant enzymes superoxide dismutase (sod) and catalase in the cytosolic fractions of substantia nigra (sn), employing spectrophotometric procedures. |
2007-06-14 |
2023-08-12 |
rat |
| b' Pavel Ressner, David Skoloud\\xc3\\xadk, Petr Hlust\\xc3\\xadk, Petr Kanovsk\\xc3\\xb. Hyperechogenicity of the substantia nigra in Parkinson\'s disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 17. issue 2. 2007-06-13. PMID:17441838.' |
substantia nigra (sn) was assessed by transcranial sonography (tcs) in 47 parkinson's disease (pd) patients and in 39 healthy volunteers. |
2007-06-13 |
2023-08-12 |
human |
| Deepinder Kaur, Subramanian Rajagopalan, Shankar Chinta, Jyothi Kumar, Donato Di Monte, Robert A Cherny, Julie K Anderse. Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Brain research. vol 1140. 2007-06-01. PMID:16631136. |
ferritin elevation has been reported by some laboratories to occur within the substantia nigra (sn), the area of the brain affected in parkinson's disease (pd), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. |
2007-06-01 |
2023-08-12 |
Not clear |
| A Lessard, E F Grady, N W Bunnett, V M Picke. Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17197098. |
neurokinin-3 (nk(3)) receptors are prevalent within the substantia nigra (sn) and ventral tegmental area (vta), where their activation can affect motor and motivational behaviors as well as cardiovascular function and stress responses. |
2007-05-21 |
2023-08-12 |
rat |
| Walter Maetzler, Daniela Berg, Natalie Schalamberidze, Arthur Melms, Klaus Schott, Jakob C Mueller, Lucy Liaw, Thomas Gasser, Cordula Nitsc. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17188882. |
we have studied in pd patients serum and cerebrospinal fluid (csf) concentrations of opn, its immunohistochemical presence in substantia nigra (sn) and tested in opn-null mice the impact of this protein on mptp-induced neurodegeneration. |
2007-05-17 |
2023-08-12 |
mouse |
| Tiziana Florio, Eugenio Scarnati, Giuseppina Confalone, Daniela Minchella, Salvatore Galati, Paolo Stanzione, Alessandro Stefani, Paolo Mazzon. High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat. The European journal of neuroscience. vol 25. issue 4. 2007-05-17. PMID:17331213. |
because the ppn receives fibres from the subthalamic nucleus (stn), we investigated the effects of stn-high-frequency stimulation (hfs) on ppn neuronal activity in intact rats and in rats bearing either an ibotenate lesion of the entopeduncular nucleus (ep) or a lesion of the substantia nigra (sn). |
2007-05-17 |
2023-08-12 |
rat |
| E Sofic, A Sapcanin, I Tahirovic, I Gavrankapetanovic, K Jellinger, G P Reynolds, T Tatschner, P Riedere. Antioxidant capacity in postmortem brain tissues of Parkinson's and Alzheimer's diseases. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447414. |
the aim of this study was to investigate the antioxidant capacity in postmortem motor cortex (mc), nucleus caudatus (nc), gyrus temporalis (gt) and substantia nigra (sn) from controls (c) and patients with pd and ad. |
2007-05-17 |
2023-08-12 |
human |
| J Salazar, N Mena, M T Núñe. Iron dyshomeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447431. |
the work of youdim and collaborators has been fundamental in describing the accumulation of iron confined to the substantia nigra (sn) in parkinson's disease (pd) and to clarify iron toxicity pathways and oxidative damage in dopaminergic neurons. |
2007-05-17 |
2023-08-12 |
Not clear |
| Wei-Guo Liu, Guo-Qiang Lu, Biao Li, Sheng-Di Che. Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 2. 2007-05-15. PMID:16963309. |
in addition, inverse transfer of ntn protein into the substantia nigra (sn) was able to protect dopaminergic neurons from 6-ohda toxicity. |
2007-05-15 |
2023-08-12 |
rat |
| F Tribl, K Marcus, H E Meyer, G Bringmann, M Gerlach, P Riedere. Subcellular proteomics reveals neuromelanin granules to be a lysosome-related organelle. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755378. |
nm granules are pigmented organelles, which are mainly found in the catecholaminergic neurons of the human substantia nigra (sn) pars compacta and the locus coeruleus. |
2007-05-08 |
2023-08-12 |
human |
| F A Zucca, C Bellei, S Giannelli, M R Terreni, M Gallorini, E Rizzio, G Pezzoli, A Albertini, L Zecc. Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755380. |
in this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (lc) and substantia nigra (sn), known targets of parkinson's disease (pd) and related disorders. |
2007-05-08 |
2023-08-12 |
human |
| D Ber. In vivo detection of iron and neuromelanin by transcranial sonography--a new approach for early detection of substantia nigra damage. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755382. |
in more than 90% of patients with idiopathic parkinson's disease (pd) hyperechogenicity of the substantia nigra (sn) can be found by transcranial sonography (tcs) as a typical, stable sign. |
2007-05-08 |
2023-08-12 |
human |
| Chaohui Zhao, Zaodung Ling, Mary B Newman, Ankush Bhatia, Paul M Carve. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17234424. |
following intraparenchymal injection of the dopamine (da) neurotoxin 6-hydroxydopamine, we previously demonstrated passage of fluoresceinisothiocyanate-labeled albumin (fitc-la) from blood into the substantia nigra (sn) and striatum suggesting damage to the blood-brain barrier (bbb). |
2007-05-08 |
2023-08-12 |
mouse |
| Shalom Michaeli, Gülin Oz, Dennis J Sorce, Michael Garwood, Kamil Ugurbil, Stacy Majestic, Paul Tuit. Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 3. 2007-05-01. PMID:17149719. |
postmortem demonstration of increased iron in the substantia nigra (sn) is a well-appreciated finding in parkinson's disease (pd). |
2007-05-01 |
2023-08-12 |
human |
| Heike Stockner, Martin Sojer, Klaus Seppi K, Joerg Mueller, Gregor K Wenning, Christoph Schmidauer, Werner Poew. Midbrain sonography in patients with essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 3. 2007-05-01. PMID:17226854. |
hyperechogenicity of the substantia nigra (sn) is a common transcranial sonography (tcs) finding in pd and has been suggested as a pd risk-marker in nonparkinsonian subjects. |
2007-05-01 |
2023-08-12 |
human |
| Jeong-Min Kim, Kyu-Hwa Lee, Yeo-Jin Jeon, Jung-Hwa Oh, So-Young Jeong, In-Sung Song, Jin-Man Kim, Dong-Seok Lee, Nam-Soon Ki. Identification of genes related to Parkinson's disease using expressed sequence tags. DNA research : an international journal for rapid publication of reports on genes and genomes. vol 13. issue 6. 2007-04-26. PMID:17213182. |
in a search for novel target genes related to parkinson's disease (pd), two full-length cdna libraries were constructed from a human normal substantia nigra (sn) and a pd patient's sn. |
2007-04-26 |
2023-08-12 |
mouse |
| B F Boeve, D W Dickson, E J Olson, J W Shepard, M H Silber, T J Ferman, J E Ahlskog, E E Benarroc. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep medicine. vol 8. issue 1. 2007-04-20. PMID:17157062. |
due to the severe neuronal loss and gliosis in the substantia nigra (sn) and locus ceruleus (lc) in this case, degeneration of brainstem monoaminergic neurons was postulated as the underlying substrate for rbd. |
2007-04-20 |
2023-08-12 |
human |
| S Urakawa, H Hida, T Masuda, S Misumi, T-S Kim, H Nishin. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17161913. |
striatal damage was induced at an age of 8 weeks by injection of the neuro-toxins 6-hydroxydopamine (6-ohda) or quinolinic acid (qa) into the striatum, or by injection of 6-ohda into the substantia nigra (sn), which depleted nigrostriatal dopaminergic innervation. |
2007-04-11 |
2023-08-12 |
rat |
| T M Korotkova, B P Klyuch, A A Ponomarenko, J S Lin, H L Haas, O A Sergeev. Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology. vol 52. issue 2. 2007-04-10. PMID:17070873. |
we investigated the modafinil action on identified dopaminergic and gabaergic neurons in the ventral tegmental area (vta) and substantia nigra (sn) of rat brain slices. |
2007-04-10 |
2023-08-12 |
rat |